BCDO2 Inhibitors
BCDO2 Inhibitors are a class of compounds that have the potential to indirectly suppress the activity of the enzyme BCDO2, which is involved in the cleavage of beta-carotene into retinal, an important step in the synthesis of vitamin A. These inhibitors do not directly target BCDO2; rather, they affect various pathways and processes that can lead to the downregulation of BCDO2's function. For example, bisphenol A, an endocrine disruptor, can alter hormonal balances that regulate the expression and activity of enzymes involved in metabolic pathways. Such endocrine disruption can indirectly lead to a decrease in BCDO2 activity by affecting the metabolic state in which BCDO2 functions optimally.
Compounds such as triclosan and phthalates can also influence BCDO2 activity by altering lipid metabolism or hormone activity, potentially reducing the availability of beta-carotene, the substrate for BCDO2. Heavy metals like lead, arsenic, cadmium, and mercury may interfere with the enzyme's activity by displacing metal co-factors, binding to sulfhydryl groups, or causing oxidative damage. These disruptions can compromise the structural integrity or catalytic function of BCDO2, leading to reduced enzyme activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A is known to disrupt endocrine function by acting as an estrogen agonist. BCDO2, a protein involved in beta-carotene metabolism, could be indirectly inhibited by bisphenol A because endocrine disruptions can affect metabolic pathways by altering hormonal balances that regulate the expression and activity of certain enzymes. | ||||||
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $138.00 $400.00 | ||
Triclosan is an antimicrobial compound that can disrupt lipid synthesis. Given that BCDO2 is associated with vitamin A production from beta-carotene, a lipid-soluble compound, triclosan-induced alterations in lipid metabolism could decrease the availability of beta-carotene for BCDO2 to act upon. | ||||||
Bis(2-ethylhexyl) phthalate | 117-81-7 | sc-254975 | 1 g | $56.00 | 2 | |
Phthalates are plasticizers known to interfere with hormone activity. Hormonal imbalances can lead to alterations in metabolic processes, potentially reducing the activity of enzymes like BCDO2 that are dependent on specific metabolic states. | ||||||
Lead | 7439-92-1 | sc-250236 | 2 kg | $102.00 | ||
Lead is a heavy metal that can inhibit a variety of enzymes by displacing metal co-factors, or by oxidative stress. If BCDO2 requires specific metal ions for its catalytic activity, lead could inhibit this process directly. Additionally, oxidative stress can damage proteins and lipids, potentially affecting BCDO2's substrate or the enzyme itself. | ||||||
Atrazine | 1912-24-9 | sc-210846 | 5 g | $165.00 | 1 | |
Atrazine is an herbicide that leads to endocrine disruption. It can indirectly inhibit BCDO2 by altering hormonal control of metabolic pathways that are necessary for the optimal functioning of the enzyme. | ||||||
Arsenic sponge | 7440-38-2 | sc-278710 | 25 g | $236.00 | ||
Arsenic can interfere with sulfhydryl groups of proteins and enzymes, potentially modifying the structure and function of BCDO2. Arsenic exposure can also disrupt metabolic pathways, leading to indirect inhibition of BCDO2. | ||||||
Acrylamide Solution, 40% | 79-06-1 | sc-3721 | 1 L | $98.00 | ||
Acrylamide is a neurotoxin that can form adducts with proteins, potentially leading to the direct inhibition of BCDO2 by modifying its structure and function. Additionally, acrylamide's impact on nerve cells can disrupt normal signaling pathways that may influence BCDO2 activity. | ||||||