ATXN7L3B activators refer to a class of chemical compounds that modulate the activity of the ATXN7L3B protein, which is a component of the human cellular machinery. The name ATXN7L3B is an abbreviation found in "ataxin-7-like protein 3B," indicating that this protein is related to ataxin-7, a protein implicated in certain cellular functions. The role of ATXN7L3B in cellular processes is linked to its ability to interact with other proteins and possibly participate in the regulation of gene expression. Activators of this protein influence its behavior and thus can affect the various pathways in which ATXN7L3B is involved. Typically, to classify compounds as activators, researchers must observe an increase in the function or action of the ATXN7L3B protein upon exposure to these substances. The exact mechanism of action for these activators can vary, as they might bind directly to the ATXN7L3B protein and enhance its natural activity or they might interact with the regulatory systems that control the protein's expression levels or its post-translational modifications.
The chemical structure of ATXN7L3B activators can be diverse, encompassing small molecules, peptides, or other organic compounds that possess the capacity to interact with the protein in a manner that upregulates its activity. The specificity and affinity of these compounds for ATXN7L3B are crucial for their classification as activators, and these properties are often fine-tuned through iterative cycles of design and synthesis. In the molecular dance within the cell, these activators may affect the conformation of ATXN7L3B, stabilize its active form, or facilitate its interaction with other proteins or nucleic acids.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC) which can phosphorylate ataxin 7 like 3B, leading to its functional activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP, which activates PKA. PKA can phosphorylate proteins including ataxin 7 like 3B, thereby activating it. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin increases intracellular calcium levels which activate calcium-dependent protein kinases. These kinases can phosphorylate ataxin 7 like 3B, thereby activating it. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, which can lead to the phosphorylation and activation of a range of proteins, including ataxin 7 like 3B. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide acts as a signaling molecule that can lead to the activation of various cellular pathways including those that phosphorylate and activate ataxin 7 like 3B. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases which leads to increased phosphorylation levels of proteins, including ataxin 7 like 3B, thereby promoting its activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits phosphatases which can result in the increased phosphorylation and activation of ataxin 7 like 3B. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases, which can lead to the phosphorylation and subsequent activation of ataxin 7 like 3B. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 modulates PKC which is involved in the phosphorylation and activation of many proteins, including ataxin 7 like 3B. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin increases cytosolic calcium by inhibiting the SERCA pump, which can activate calcium-dependent kinases that phosphorylate and activate ataxin 7 like 3B. |