Date published: 2025-10-15

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ATXN7L3B Activators

ATXN7L3B activators refer to a class of chemical compounds that modulate the activity of the ATXN7L3B protein, which is a component of the human cellular machinery. The name ATXN7L3B is an abbreviation found in "ataxin-7-like protein 3B," indicating that this protein is related to ataxin-7, a protein implicated in certain cellular functions. The role of ATXN7L3B in cellular processes is linked to its ability to interact with other proteins and possibly participate in the regulation of gene expression. Activators of this protein influence its behavior and thus can affect the various pathways in which ATXN7L3B is involved. Typically, to classify compounds as activators, researchers must observe an increase in the function or action of the ATXN7L3B protein upon exposure to these substances. The exact mechanism of action for these activators can vary, as they might bind directly to the ATXN7L3B protein and enhance its natural activity or they might interact with the regulatory systems that control the protein's expression levels or its post-translational modifications.

The chemical structure of ATXN7L3B activators can be diverse, encompassing small molecules, peptides, or other organic compounds that possess the capacity to interact with the protein in a manner that upregulates its activity. The specificity and affinity of these compounds for ATXN7L3B are crucial for their classification as activators, and these properties are often fine-tuned through iterative cycles of design and synthesis. In the molecular dance within the cell, these activators may affect the conformation of ATXN7L3B, stabilize its active form, or facilitate its interaction with other proteins or nucleic acids.

SEE ALSO...

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC) which can phosphorylate ataxin 7 like 3B, leading to its functional activation.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin increases intracellular cAMP, which activates PKA. PKA can phosphorylate proteins including ataxin 7 like 3B, thereby activating it.

Ionomycin, free acid

56092-81-0sc-263405
sc-263405A
1 mg
5 mg
$94.00
$259.00
2
(2)

Ionomycin increases intracellular calcium levels which activate calcium-dependent protein kinases. These kinases can phosphorylate ataxin 7 like 3B, thereby activating it.

Insulin

11061-68-0sc-29062
sc-29062A
sc-29062B
100 mg
1 g
10 g
$153.00
$1224.00
$12239.00
82
(1)

Insulin activates the PI3K/Akt signaling pathway, which can lead to the phosphorylation and activation of a range of proteins, including ataxin 7 like 3B.

Hydrogen Peroxide

7722-84-1sc-203336
sc-203336A
sc-203336B
100 ml
500 ml
3.8 L
$30.00
$60.00
$93.00
27
(1)

Hydrogen peroxide acts as a signaling molecule that can lead to the activation of various cellular pathways including those that phosphorylate and activate ataxin 7 like 3B.

Calyculin A

101932-71-2sc-24000
sc-24000A
sc-24000B
sc-24000C
10 µg
100 µg
500 µg
1 mg
$160.00
$750.00
$1400.00
$3000.00
59
(3)

Calyculin A is an inhibitor of protein phosphatases which leads to increased phosphorylation levels of proteins, including ataxin 7 like 3B, thereby promoting its activation.

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$285.00
$520.00
$1300.00
78
(4)

Okadaic Acid inhibits phosphatases which can result in the increased phosphorylation and activation of ataxin 7 like 3B.

Anisomycin

22862-76-6sc-3524
sc-3524A
5 mg
50 mg
$97.00
$254.00
36
(2)

Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases, which can lead to the phosphorylation and subsequent activation of ataxin 7 like 3B.

Bryostatin 1

83314-01-6sc-201407
10 µg
$240.00
9
(1)

Bryostatin 1 modulates PKC which is involved in the phosphorylation and activation of many proteins, including ataxin 7 like 3B.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$94.00
$349.00
114
(2)

Thapsigargin increases cytosolic calcium by inhibiting the SERCA pump, which can activate calcium-dependent kinases that phosphorylate and activate ataxin 7 like 3B.