ACAT-1 Inhibitors

Acetyl-CoA acetyltransferase (ACAT), also known as acetoacetyl-CoA thiolase or 3-ketoacyl-CoA thiolase, is an enzyme involved in the metabolism of fatty acids and ketone bodies. It catalyzes the reversible transfer of an acetyl group from acetyl-CoA to another molecule, forming acetoacetyl-CoA. The primary function of ACAT is to catalyze the thiolysis of acetyl-CoA, which is an important step in the beta-oxidation of fatty acids. During beta-oxidation, long-chain fatty acids are broken down in the mitochondria to generate acetyl-CoA, which can enter the citric acid cycle to produce energy. ACAT cleaves acetyl-CoA into two molecules of acetyl-CoA to continue the beta-oxidation process. ACAT also plays a crucial role in ketone body metabolism. Ketone bodies, such as acetoacetate and beta-hydroxybutyrate, are alternative energy sources produced by the liver during periods of fasting, low carbohydrate intake, or intense exercise. ACAT catalyzes the synthesis of acetoacetyl-CoA, which is an intermediate in the production of ketone bodies. The activity of ACAT is regulated by various factors. One important regulator is the concentration of acetyl-CoA. High levels of acetyl-CoA promote the catalytic activity of ACAT, while low levels inhibit it. The enzyme is also subject to regulation by post-translational modifications and interactions with other proteins. In summary, acetyl-CoA acetyltransferase (ACAT) is an enzyme involved in fatty acid metabolism and the synthesis of ketone bodies. It plays a critical role in energy production and is regulated by various factors. Dysregulation of ACAT can lead to metabolic disorders, and the enzyme is a target for interventions. ACAT-1 inhibitors offered by Santa Cruz Biotechnology inhibit ACAT-1 and, in some cases, other thiolase proteins.