Topo I Inhibitors

Santa Cruz Biotechnology now offers a broad range of Topo I Inhibitors. DNA topoisomerase I and II (Topo I and Topo II) are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Topo I Inhibitors offered by Santa Cruz inhibit Topo I and, in some cases, other DNA replication and recombination related proteins. View detailed Topo I Inhibitor specifications, including Topo I Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.

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PRODUCT NAME/Application CAS Catalog # QUANTITY Price Citations RATING
Suramin sodium
129-46-4 sc-507209
sc-507209F
sc-507209A
sc-507209B
sc-507209C
sc-507209D
sc-507209E
50 mg
100 mg
250 mg
1 g
10 g
25 g
50 g
$100.00
$200.00
$300.00
$850.00
$8,500.00
$20,990.00
$39,500.00
1
(1)
beta-Lapachone
β-Lapachone is a selective DNA topoisomerase I inhibitor
4707-32-8 sc-200875
sc-200875A
5 mg
25 mg
$90.00
$324.00
7
(1)
SN 38
SN 38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11), able to inhibit DNA topoisomerase I.
86639-52-3 sc-203697
sc-203697A
sc-203697B
10 mg
50 mg
500 mg
$109.00
$323.00
$860.00
19
(3)
NU 1025
NU 1025 is a potent PARP-1 and Topo I inhibitor
90417-38-2 sc-203166
5 mg
$131.00
8
(1)
Ellagic Acid, Dihydrate
Ellagic Acid, Dihydrate is a CK2, Topo I and II, FGR, GSK, and PKA inhibitor
476-66-4 sc-202598
sc-202598A
sc-202598B
sc-202598C
500 mg
5 g
25 g
100 g
$50.00
$85.00
$229.00
$693.00
5
(1)
Luteolin
Luteolin is an inhibitor of LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocker of NF-κB and AP-1 activation.
491-70-3 sc-203119
sc-203119A
sc-203119B
sc-203119C
sc-203119D
5 mg
50 mg
500 mg
5 g
500 g
$20.00
$25.00
$60.00
$80.00
$1,850.00
30
(1)
3-O-Acetyl-β-boswellic acid
3-O-Acetyl-β-boswellic acid is a non-competitive 5-lipoxygenase and topoisomerase I and IIa
5968-70-7 sc-202885
sc-202885A
1 mg
5 mg
$55.00
$123.00
0
(1)
Sedanolide
Sedanolide is an inducer of GST and inhibitor of Cox-1, Cox-2, Topo I, Topo II, and carcinogenesis
6415-59-4 sc-205972
100 mg
$148.00
0
(1)
(S)-10-Hydroxycamptothecin
(S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase I
19685-09-7 sc-205614
sc-205614A
25 mg
100 mg
$58.00
$165.00
3
(1)
Irinotecan-d10 Hydrochloride
Irinotecan-d10 Hydrochloride is a deuterated DNA Topo I inhibitor
718612-62-5 sc-280849
sc-280849A
1 mg
10 mg
$250.00
$2,000.00
8
(1)
Topotecan Hydrochloride
Topotecan Hydrochloride is a water-soluble inhibitor of DNA Topo I
119413-54-6 sc-204919
sc-204919A
1 mg
5 mg
$34.00
$93.00
0
(1)
Acetyl-11-keto-beta-Boswellic Acid, Boswellia serrata
Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata is a 5-LO and topo I and II inhibitor
67416-61-9 sc-221208
5 mg
$164.00
0
(1)
Daunorubicin hydrochloride
Daunorubicin hydrochloride is a DNA intercalator which may suppress acute leukemia proliferation
23541-50-6 sc-200921
sc-200921A
sc-200921B
sc-200921C
10 mg
50 mg
250 mg
1 g
$96.00
$416.00
$800.00
$1,503.00
4
(1)
Rebeccamycin
Rebeccamycin is an indolocarbazole topoisomerase inhibitor
93908-02-2 sc-202309
sc-202309A
250 µg
1 mg
$83.00
$300.00
0
(0)
Irinotecan hydrochloride trihydrate
Irinotecan hydrochloride trihydrate is an inhibitor of Topo I
136572-09-3 sc-202186
sc-202186A
5 mg
25 mg
$93.00
$341.00
6
(1)
Rubitecan
Rubitecan is a DNA topoisomerase I inhibitor
91421-42-0 sc-219998
10 mg
$86.00
1
(0)
Irinotecan Carboxylate Sodium Salt
Irinotecan Carboxylate Sodium Salt is a carboxylated Topo I inhibitor
sc-280848
5 mg
$320.00
0
(0)
Thiocolchicine
Thiocolchicine is a specific tubulin synthesis inhibitor and Topo I inhibitor
2730-71-4 sc-202838
sc-202838A
100 mg
5 mg
$194.00
$125.00
0
(1)
7-Ethyl Camptothecin
7-Ethyl Camptothecin is an anti-cancer agent and Topo I inhibitor
78287-27-1 sc-207171
10 mg
$228.00
0
(0)
9-Aminocamptothecin
9-Aminocamptothecin is an active derivative of camptothecin and topoisomerase inhibitor
91421-43-1 sc-205615
sc-205615A
10 mg
25 mg
$160.00
$331.00
1
(0)
(+)-Irinotecan
(+)-Irinotecan is a Topo I inhibitor
97682-44-5 sc-269253
10 mg
$60.00
0
(1)
Topotecan
Topotecan is a topo I inhibitor shown to stabilize topo I/DNA cleavable complexes
123948-87-8 sc-338718
100 mg
$560.00
0
(0)
Reticulol
Reticulol is an isocoumarin metabolite shown to inactivate topoisomerase I
26246-41-3 sc-202313
sc-202313A
250 µg
1 mg
$100.00
$213.00
0
(0)
Sodium Camptothecin
Sodium Camptothecin is the salt form of Camptothecin
25387-67-1 sc-338592
1 g
$700.00
0
(0)
7-Ethyl-d3-camptothecin
7-Ethyl-d3-camptothecin is a deuterium labeled Topo I inhibitor
1217626-02-2 sc-217437
1 mg
$490.00
0
(0)
Irinotecan Labeled d10
Irinotecan Labeled d10 is a deuterated DNA Topo I inhibitor
97682-44-5 (unlabeled) sc-353632
10 mg
$2,540.00
2
(0)
Topotecan Hydrochloride Labeled d6
Topotecan Hydrochloride Labeled d6 is an isotope labeled Topo I inhibitor
119413-54-6 (unlabeled) sc-356167
10 mg
$2,000.00
0
(0)
11-Ethyl Camptothecin
11-Ethyl Camptothecin is a substituted Topo I inhibitor
185807-29-8 sc-213584
10 mg
$31,500.00
0
(0)
Genz 644282
Genz 644282 is A Topo I (topoisomerase I) inhibitor
529488-28-6 sc-396035
5 mg
$155.00
0
(0)
Topotecan-d6
Topotecan-d6 is a labeled DNA Topo I (topoisomerase I) inhibitor
1044904-10-0 sc-220273
1 mg
$340.00
0
(0)
2prime,3prime-Dideoxyadenosine-5prime-triphosphate Lithium Salt
93939-70-9 sc-288569
sc-288569A
1 mg
5 mg
$237.00
$945.00
0
(0)