Santa Cruz Biotechnology offers an expansive library of transfected lysates that overexpress tumor suppressor and apoptosis proteins. Tumor suppressor proteins reduce the probability that a cell in a multicellular organism will become cancerous. Tumor suppressors have a repressive effect on the regulation of the cell cycle and/or are involved in the induction or inhibition of apoptosis via various mechanisms. A mutation or deletion in a gene encoding for a tumor suppressor increases the probability of the formation of a tumor. In addition to cell cycle regulation and apoptosis promotion, some of the functions of tumor suppressors include: signaling through adhesion molecules to the nucleus, transcriptional regulation, transmembrane reception, activation through phosphorylation, and DNA mismatch repair. Transfected lysates that express tumor suppressor and apoptosis proteins offer a reliable means to evaluate antibody quality and serve as excellent positive controls for experiments involving antibodies.
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