Santa Cruz Biotechnology offers an expansive library of transfected lysates that overexpress channel proteins. Channel proteins, such as the ubiquitously expressed sodium/potassium-ATPase (Na+/K+-ATPase), exist as an oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na+ ions and two K+ ions against their respective electrochemical gradients. As a member of the P-type family of ion motives, Na+/K+-ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport. Transfected lysates that express channel proteins offer a reliable means to evaluate antibody quality and serve as excellent positive controls for experiments involving antibodies.
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