Santa Cruz Biotechnology offers an expansive library of transfected lysates that overexpress cell adhesion proteins. Cell adhesion molecules (CAMs) influence cell growth, differentiation, embryogenesis, immune response and cancer metastasis by networking information from the extracellular matrix to the cell. The four major families of cell adhesion molecules are immunoglobulin (Ig) superfamily (calcium-independent transmembrane glycoproteins), integrins (transmembrane non-covalently linked heterodimers of a and b subunits), calcium-dependent cadherins and divalent cation-dependent selectins. Mutation of CAM genes has been linked to several forms of cancer, effecting tumor growth and metastasis. Such important cell adhesion proteins include β-catenin, connexin, p120 and paxillin. Transfected lysates that express cell adhesion proteins offer a reliable means to evaluate antibody quality and serve as excellent positive controls for experiments involving antibodies.
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