PDE Inhibitors

Santa Cruz Biotechnology now offers a broad range of PDE Inhibitors. Phosphodiesterases (PDEs) are important regulators of signal transduction by facilitating the degradation of the cyclic nucleotide secondary messengers cAMP and cGMP. The PDE family contains proteins that serve tissue-specific roles in regulation of lipolysis, glycogenolysis, myocardial contractility, and smooth muscle relaxation. View detailed PDE Inhibitor specifications, including PDE Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.

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ChemCruz™ Chemical PDE Activators or PDE Substrates for functional analysis of cellular responses to PDE

PRODUCT NAME/Application	CAS	Catalog #	QUANTITY	Price	Citations	RATING
Ketotifen fumarate A histamine H1 antagonist and mast cell growth inhibitor	34580-14-8	sc-201094 sc-201094A	1 g 100 mg	$62.00 $39.00	3	(1)
BRL-50481 BRL-50481 is a selective inhibitor of PDE 7	433695-36-4	sc-201178 sc-201178A	10 mg 50 mg	$72.00 $272.00	2	(0)
Caffeine Caffeine is an adenosine receptor antagonist and cAMP phosphodiesterase inhibitor	58-08-2	sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D	5 g 100 g 250 g 1 kg 5 kg	$20.00 $37.00 $55.00 $150.00 $700.00	10	(1)
Vardenafil-d5 Vardenafil-d5 is a detuerium-labeled PDE (phosphodiesterase) inhibitor	1189685-70-8	sc-220369	1 mg	$280.00	1	(0)
Roflumilast Roflumilast is a selective inhibitor of PDE4 (phosphodiesterase 4)	162401-32-3	sc-208313	5 mg	$52.00	21	(1)
IBMX IBMX is a potent and nonspecific inhibitor of PDE (phosphodiesterases) and can increase intracellular cyclic AMP levels	28822-58-4	sc-201188 sc-201188B sc-201188A	200 mg 500 mg 1 g	$65.00 $113.00 $155.00	27	(1)
Furafylline Furafylline is an inhibitor of Cytochrome P450 (CYP1A2) and phosphodiesterase (PDE)	80288-49-9	sc-215061	5 mg	$278.00	2	(1)
8-CPT-cAMP 8-CPT-cAMP is an efficient activator of cGK and cAMP-PK, and inhibitor of PDE	93882-12-3	sc-201569 sc-201569A	20 mg 100 mg	$75.00 $285.00	18	(1)
Prazosin hydrochloride Prazosin hydrochloride is an andrenergic α₁, α_2B-adrenoceptor, & MT3 receptor antagonist	19237-84-4	sc-204858	100 mg	$79.00	3	(1)
EHNA hydrochloride EHNA hydrochloride is an inhibitor of adenosine deaminase and cyclic nucleotide PDE2 (phosphodiesterase- 2)	51350-19-7	sc-201184 sc-201184A	10 mg 50 mg	$89.00 $355.00	5	(1)
Vardenafil Vardenafil is a selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5)	224785-90-4	sc-362054 sc-362054A sc-362054B	100 mg 1 g 50 g	$440.00 $550.00 $16,000.00	5	(1)
Papaverine hydrochloride Papaverine hydrochloride is an alkaloid that may inhibit phosphodiesterases and/or calcium channel actions	61-25-6	sc-202273	5 g	$30.00	4	(1)
5prime-Deoxy-5prime-methylthioadenosine 5′-Deoxy-5′-methylthioadenosine is an endogenous methylthioadenosine phosphorylase substrate and potent inhibitor of PDE	2457-80-9	sc-202427	50 mg	$89.00	0	(1)
Quercetin Dihydrate Quercetin Dihydrate is a natural flavonoid antiproliferative kinase inhibitor	6151-25-3	sc-203225 sc-203225A	5 g 25 g	$31.00 $39.00	1	(1)
Luteolin Luteolin is an inhibitor of LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocker of NF-κB and AP-1 activation.	491-70-3	sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D	5 mg 50 mg 500 mg 5 g 500 g	$20.00 $25.00 $60.00 $80.00 $1,850.00	26	(1)
Enniatin B Enniatin B is an ionophore antibiotic that inhibits ACAT and PDE	917-13-5	sc-202150	1 mg	$141.00	4	(1)
Ophiobolin A Ophiobolin A is a sesterterpenoid fungal phytotoxin and inhibitor of calmodulin action in calcium regulation.	4611-05-6	sc-202266 sc-202266A sc-202266B	100 µg 1 mg 5 mg	$42.00 $240.00 $700.00	2	(1)
Dipyridamole Dipyridamole is a phosphodiester, cGMP, and non-specific nucleoside transport inhibitor	58-32-2	sc-200717 sc-200717A	1 g 5 g	$29.00 $98.00	0	(1)
MDL-12,330A dot HCl MDL-12,330A • HCl is an A cyclase inhibitor	40297-09-4	sc-201574 sc-201574A	5 mg 25 mg	$65.00 $269.00	11	(1)
Theobromine Theobromine is a weak phosphodiesterase inhibitor and adenosine receptor blocker	83-67-0	sc-203296 sc-203296A	25 g 100 g	$40.00 $85.00	0	(1)
Cilostamide (OPC 3689) Cilostamide (OPC 3689) is a specific phosphodiesterase 3 (PDE3) inhibitor	68550-75-4	sc-201180 sc-201180A	5 mg 25 mg	$80.00 $274.00	13	(1)
Cilostazol Cilostazol is a PDE inhibitor, antimitogenic, antithrombotic, and cardiotonic agent	73963-72-1	sc-201182 sc-201182A	10 mg 50 mg	$69.00 $285.00	3	(1)
E6 Berbamine E6 Berbamine is a selective and cell-permeable CaM antagonist	73885-53-7	sc-221573 sc-221573A	10 mg 50 mg	$120.00 $450.00	2	(1)
Butein Butein is inhibits the tyrosine kinase activity of the EGF receptor and p60c-src	487-52-5	sc-202510 sc-202510A	5 mg 50 mg	$169.00 $300.00	7	(1)
Theophylline Theophylline is an inhibitor of cyclic phosphodiesterase	58-55-9	sc-202835 sc-202835A sc-202835B	5 g 25 g 100 g	$20.00 $30.00 $81.00	6	(0)
Diphylline Diphylline is an inhibitor of phosphodiesterase	479-18-5	sc-364352	100 mg	$105.00	1	(0)
7-(beta-Hydroxyethyl)-theophylline 7-(β-Hydroxyethyl)-theophylline is a weak phosphodiesterase inhibitor & an intermediate for 7-substituted xanthine	519-37-9	sc-202836	5 g	$40.00	1	(0)
Irsogladine maleate Irsogladine maleate is a PDE4 inhibitor and muscarinic acetylcholine receptor binder	84504-69-8	sc-201190 sc-201190A	50 mg 250 mg	$64.00 $153.00	0	(0)
Malvidin chloride Malvidin chloride is a cell-cycle arresting compound	643-84-5	sc-205952	10 mg	$319.00	0	(1)
Pentoxifylline Pentoxifylline is a non-selective phosphodiesterase inhibitor. Inhibits endotoxin-induced synthesis of TNF-α	6493-05-6	sc-203184	1 g	$20.00	2	(1)
Vardenafil Dihydrochloride Salt Vardenafil Dihydrochloride Salt is a selective PDE 5 (phsphodiesterase type 5) inhibitor	224789-15-5	sc-220368 sc-220368A sc-220368B	10 mg 25 mg 50 mg	$220.00 $550.00 $700.00	0	(0)
Anagrelide hydrochloride Anagrelide hydrochloride is a potent type III phosphodiesterase inhibitor	58579-51-4	sc-203513 sc-203513A	10 mg 50 mg	$101.00 $575.00	1	(0)
Caffeine-d9 Caffeine-d9 is an inhibitory compound which acts a cardiac and respiratory stimulant	72238-85-8	sc-217818	2.5 mg	$300.00	0	(0)
Hydroxythiohomo Sildenafil Hydroxythiohomo Sildenafil is A thio analog of Sildenafil and a potential PDE5 inhibitor.	479073-82-0	sc-207746	1 mg	$300.00	0	(0)
Levosimendan Levosimendan is a Ca²⁺ sensitizer that increases contractile force of the myocardium	141505-33-1	sc-204792 sc-204792A	100 mg 250 mg	$100.00 $220.00	0	(1)
YM 976 YM 976 is an inhibitor of PDE4	191219-80-4	sc-204411 sc-204411A	10 mg 50 mg	$207.00 $825.00	0	(0)
Acetildenafil Acetildenafil is a structural analog of Sidenafil	831217-01-7	sc-207250	2.5 mg	$300.00	0	(0)
Enoximone Enoximone is a selective phosphodiesterase III (PDE3) inhibitor	77671-31-9	sc-252775 sc-252775A	10 mg 50 mg	$181.00 $728.00	1	(0)
Phosphodiesterase V Inhibitor II Phosphodiesterase V Inhibitor II is an inhibitor of phosphodiesterase		sc-222167	5 mg	$175.00	0	(0)
Dipyridamole-D20 (Major) Dipyridamole-D20 (Major) is a selective phosphodiesterase V (PDE 5) inhibitor	58-32-2 unlabeled	sc-218245	1 mg	$250.00	0	(0)
Quercetin Quercetin is a PI 3-kinase inhibitor, GPR30 activator, and apoptosis inducer	117-39-5	sc-206089 sc-206089A sc-206089B sc-206089E sc-206089C sc-206089D	100 mg 500 mg 25 g 100 g 250 g 1 kg	$10.00 $15.00 $39.00 $100.00 $240.00 $900.00	21	(2)
Aminophylline Aminophylline is a non-selective PDE (phosphodiesterase)inhibitor	317-34-0	sc-252368	25 g	$35.00	0	(0)
Theophylline monohydrate Theophylline monohydrate is an inhibitor of PDE	5967-84-0	sc-280133	50 g	$41.00	0	(0)
ICI 63197 ICI 63197 is an inhibitor of phosphodiesterase 4 competitive with rolipram	27277-00-5	sc-203600 sc-203600A	10 mg 50 mg	$140.00 $575.00	0	(0)
Zaprinast (MB 22948) Zaprinast (M&B 22948) is an inhibitor of cGMP-specific phosphodiesterase	37762-06-4	sc-201206 sc-201206A	25 mg 100 mg	$80.00 $215.00	6	(2)
Vinpocetine Vinpocetine is an inhibitor of Ca²⁺/CaM-PDE with neuroprotective properties	42971-09-5	sc-201204 sc-201204A sc-201204B	20 mg 100 mg 15 g	$55.00 $214.00 $2,400.00	4	(1)
Etazolate Hydrochloride Etazolate Hydrochloride is a potent inhibitor of cAMP phosphodiesterase (PDE4) and less potent cGMP phosphodiesterase inhibitor	35838-58-5	sc-201186 sc-201186A	5 mg 25 mg	$59.00 $245.00	5	(0)
Denbufylline Denbufylline is a xanthine derivative PDE IV inhibitor	57076-71-8	sc-203915	5 mg	$190.00	0	(0)
W-5 W-5 is a CaM antagonist that inhibits Ca²⁺/calmodulin- regulated activities	61714-25-8	sc-201500 sc-201500A	25 mg 500 mg	$66.00 $630.00	2	(1)
Doxofylline Doxofylline is a xanthine bronchodilator known to impede phosphodiesterase activities	69975-86-6	sc-205658 sc-205658A	1 g 5 g	$80.00 $220.00	1	(1)
Quazinone (Ro 13-6438) Quazinone (Ro 13-6438) is a phosphodiesterase inhibitor and novel cardiotonic agent with vasodilating properties	70018-51-8	sc-201196 sc-201196A	10 mg 50 mg	$85.00 $328.00	0	(0)
8-Methoxymethyl-IBMX 8-Methoxymethyl-IBMX is a Cam-PDE selective inhibitor	78033-08-6	sc-201192 sc-201192A	10 mg 50 mg	$260.00 $1,150.00	2	(0)
Milrinone Milrinone is a phosphodietsterase 3 inhibitor	78415-72-2	sc-201193 sc-201193A	10 mg 50 mg	$159.00 $670.00	6	(0)
MY-5445 MY-5445 is a selective cGMP phosphodiesterase inhibitor	78351-75-4	sc-201195	10 mg	$153.00	2	(1)
Trequinsin hydrochloride Trequinsin hydrochloride is an ultrapotent inhibitor of phosphodiesterase 3	78416-81-6	sc-358713	10 mg	$235.00	0	(0)
S-(+)-Rolipram S-(+)-Rolipram is an inhibitor of cyclic AMP-specific phosphodiesterase	85416-73-5	sc-201200	5 mg	$147.00	0	(0)
R-(-)-Rolipram R-(−)-Rolipram is a PDE IV inhibitor and anti-inflammatory agent	85416-75-7	sc-201199	5 mg	$158.00	0	(0)
LY 171883 LY 171883 is a selective leukotriene D4 antagonist	88107-10-2	sc-203120	10 mg	$72.00	0	(0)
Zardaverine Zardaverine is a pyridazinone derivative and a selective inhibitor of phosphodiesterase type III and IV	101975-10-4	sc-201208 sc-201208A	5 mg 25 mg	$86.00 $372.00	1	(0)
Siguazodan Siguazodan is A selective phosphodiesterase PDE III inhibitor and a potent inotropic agent	115344-47-3	sc-201201 sc-201201A	5 mg 25 mg	$100.00 $398.00	0	(0)
CP 80633 CP 80633 is a selective inhibitor of phosphodiesterase type 4	135637-46-6	sc-205276 sc-205276A	10 mg 50 mg	$205.00 $810.00	0	(0)
Ibudilast Ibudilast is a nonselective phosphodiesterase inhibitor	50847-11-5	sc-203080	10 mg	$210.00	1	(1)
Mesopram Mesopram is an active phosphodiesterase (PDE) 4 inhibitor	189940-24-7	sc-204077 sc-204077A	10 mg 50 mg	$175.00 $739.00	0	(1)
Reticulol Reticulol is an isocoumarin metabolite shown to inactivate topoisomerase I	26246-41-3	sc-202313 sc-202313A	250 µg 1 mg	$100.00 $213.00	0	(0)
1,3-Dipropylxanthine 1,3-Dipropylxanthine is an inhibitor of PDE (phosphodiesterase)	31542-62-8	sc-213513	50 mg	$240.00	0	(0)
Cilomilast-d9 Cilomilast-d9 is a deuterium-labeled PDE (phosphodiesterase) inhibitor	153259-65-5 (unlabeled)	sc-217896	1 mg	$300.00	0	(0)
Roflumilast-d3 Roflumilast-d3 is a deuterium-labeled PDE4 inhibitor	1189992-00-4	sc-219987	1 mg	$300.00	0	(0)
Phosphodiesterase 4 Inhibitor Phosphodiesterase 4 Inhibitor is a pyrazole compound with an active site binding inhibitor of phosphodiester	346440-86-6	sc-204190 sc-204190A	10 mg 50 mg	$280.00 $1,300.00	0	(0)
Anagrelide-13C3 Anagrelide-13C3 is a labeled type III phosphodiesterase inhibitor		sc-217646	1 mg	$450.00	0	(0)
Tadalafil-methyl-d3 Tadalafil-methyl-d3 is a deuterium-labeled phosphodiesterase inhitibor		sc-220184	1 mg	$300.00	0	(0)
W-12, hydrochloride A calmodulin antagonist that inhibits myosin light chain kinase	89108-46-3	sc-203309	1 mg	$115.00	0	(0)
Obscurolide A1 Obscurolide A₁ is a weak PDE (phosphodiesterase) inhibitor isolated from Streptomyces viridochromogenes	144397-99-9	sc-203167 sc-203167A	1 mg 5 mg	$90.00 $360.00	0	(0)
Icariin Icariin is an inhibitor of recombinant PDE5	489-32-7	sc-279198 sc-279198A sc-279198B	1 g 5 g 10 g	$134.00 $400.00 $793.00	0	(1)
BAY-60-7550 BAY-60-7550 is a selective and potent PDE2 inhibitor, potentially useful for enhancing cAMP/cGMP-mediated object and spatial memory consolidation.	439083-90-6	sc-396772 sc-396772A	1 mg 5 mg	$150.00 $450.00	7	(1)
Amrinone Amrinone is a selective cAMP phosphodiesterase inhibitor	60719-84-8	sc-207288	1 g	$153.00	0	(1)
GSK256066 GSK256066 is a highly potent and selective inhibitor of phosphodiesterase 4	801312-28-7	sc-364353 sc-364353A	10 mg 50 mg	$555.00 $1,600.00	0	(0)
1-Methyl-4-nitro-5-propyl-1H-pyrazole-3-carboxamide 1-Methyl-4-nitro-5-propyl-1H-pyrazole-3-carboxamide is an intermediate in the preparation of cGMP PDE5 inhibitors	247583-72-8	sc-397129	10 mg	$250.00	0	(0)
1,3-Dipropyl-7-methylxanthine 1,3-Dipropyl-7-methylxanthine is A PDE inhibitor.	31542-63-9	sc-206245	25 mg	$210.00	0	(0)
4-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide 4-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide is a hypolipidemic and possible PDE1 inhibitor	139756-02-8	sc-357666	1 g	$74.00	0	(0)
Dipyridamole Di-O-beta-D-glucuronide Dipyridamole Di-O-β-D-glucuronide is a metabolite of dipyridamole, a PDE 5 inhibitor	107136-95-8	sc-221552	1 mg	$420.00	0	(0)
Tadalafil Tadalafil is a phosphodiesterase 5 inhibitor	171596-29-5	sc-208412	50 mg	$126.00	11	(2)
N-Desethyl Acetildenafil	147676-55-9	sc-208022	2.5 mg	$350.00	0	(0)
Avanafil Avanafil is a derivative of pyrimidine that acts as PDE5 (phosphodiesterase-5) inhibitor	330784-47-9	sc-397683 sc-397683A sc-397683B sc-397683C sc-397683D	10 mg 100 mg 1 g 5 g 50 g	$220.00 $350.00 $450.00 $900.00 $8,000.00	1	(0)
Hydroxy vardenafil Hydroxy vardenafil is A PDE 5 inhibitor.	224785-98-2	sc-488984	2.5 mg	$300.00	0	(0)
Pentoxifylline-d6 Pentoxifylline-d6 is a labeled metabolite of pentifylline	1185878-98-1	sc-219571	1 mg	$350.00	0	(0)
Sildenafil-d3 Sildenafil-d3 is a deuterium-labelled analog of Sildenafil	1126745-90-1	sc-220101	1 mg	$220.00	0	(0)
Propoxyphenyl Thioaildenafil Propoxyphenyl Thioaildenafil is An inhibitor of PDE.	856190-49-3	sc-477058	5 mg	$300.00	0	(0)
Papaverine Papaverine is a phosphodiesterase inhibitor	58-74-2	sc-279951 sc-279951A sc-279951B	10 mg 50 mg 100 mg	$150.00 $260.00 $450.00	0	(0)
4-{[3prime,4prime-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline 4-{[3′,4′-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline is an inhibitor of cGMP-specific phosphodiesterase	150450-42-3	sc-352371	1 mg	$140.00	0	(0)
Paraxanthine Paraxanthine is an adenosine receptor ligand and a major metabolite of caffeine	611-59-6	sc-212526A sc-212526B sc-212526 sc-212526C sc-212526D sc-212526E	25 mg 50 mg 100 mg 250 mg 500 mg 1 g	$130.00 $190.00 $280.00 $620.00 $1,100.00 $1,950.00	0	(1)
Tropinone Tropinone is A PDE 4 (Phosphodiesterase IV) inhibitor.	532-24-1	sc-253807 sc-253807A	5 g 10 g	$35.00 $65.00	1	(0)
Rolipram Rolipram is a selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4)	61413-54-5	sc-3563 sc-3563A	5 mg 50 mg	$64.00 $197.00	17	(1)
Gisadenafil besylate Gisadenafil besylate is a PDE5 inhibitor	334827-98-4	sc-361185 sc-361185A	5 mg 25 mg	$97.00 $368.00	0	(0)
CDP 840 hydrochloride CDP 840 hydrochloride is a selective and potent inhibitor of PDE 4	162542-90-7	sc-362723 sc-362723A	10 mg 50 mg	$175.00 $739.00	0	(0)
BC 11-38 BC 11-38 is a selective inhibitor of phosphodiesterase 11	686770-80-9	sc-364350 sc-364350A	10 mg 50 mg	$160.00 $642.00	0	(0)
PF-2545920 PF-2545920 is an inhibitor of PDE10A (phosphodiesterase 10A)	1292799-56-4	sc-364355 sc-364355A	5 mg 10 mg	$405.00 $555.00	0	(0)
Quercetin-d3 (Major) Quercetin-d3 (Major) is is the isotope labelled analogue of Quercetin (sc-206089),which is a mitochondrial ATPase and PDE (phosphodiesterase) inhibitor.	263711-79-1	sc-476756	2.5 mg	$300.00	0	(0)
Anagrelide Anagrelide is a PDE 3 (Phosphodiesterase 3) Inhibitor	68475-42-3	sc-491875	25 mg	$147.00	0	(0)

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PDE Inhibitors

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