GABA Metabolism and Transport

Santa Cruz Biotechnology now offers a broad range of GABA Metabolism and Transport products. γ-Aminobutyric acid, or GABA, is the main inhibitory neurotransmitter relied upon by the central nervous system of most mammals. Generally, binding of a receptor by GABA causes inhibition due to hyperpolarization, although the exact underlying processes vary amongst receptor types. There is also evidence that GABA first possesses excitatory functions during the neonatal stage, then becomes inhibitory during development and adulthood. During development, it helps regulate the growth and differentiation of progenitor cells, and it is also necessary for maintaining muscle tone. GABA activity at the synapse is terminated when the neurotransmitter is taken up by the presynaptic nerve and local glial cells, a process mediated by temperature- and ion-dependent membrane transport systems. GABA is conserved via the GABA shunt pathway, a closed-loop process which metabolizes glutamate to form GABA, then converts GABA back into its precursor. GABA Metabolism and Transport products are useful for studying these pathways and the effects these can have on multiple physiological systems. Our popular products such as (-)-Bicuculline methobromide and Riluzole are typically available for immediate shipment.

indicates a highly recommended product based on customer preference.

PRODUCT NAME/Application CAS Catalog # QUANTITY Price Citations RATING
(-)-Bicuculline methobromide
(−)-Bicuculline methobromide is an N-methylated derivative of the GABAA antagonist bicuculline
73604-30-5 sc-200436
50 mg
$143.00
0
(1)
DHEA
DHEA is a negative modulator of GABAA receptors
53-43-0 sc-202573
10 g
$101.00
1
(1)
Riluzole
Riluzole is a sodium channel protein inhibitor
1744-22-5 sc-201081
sc-201081A
sc-201081B
sc-201081C
20 mg
100 mg
1 g
25 g
$15.00
$180.00
$200.00
$300.00
0
(1)
Etomidate
Etomidate is a GABAA receptors agonist
33125-97-2 sc-203577
10 mg
$122.00
0
(0)
NNC 711
NNC 711 is a potent and selective inhibitor of GABA T-1
145645-62-1 sc-204132
sc-204132A
5 mg
25 mg
$116.00
$301.00
0
(0)
CGP 54626 hydrochloride
CGP 54626 hydrochloride is a potent and selective GABA b receptor antagonist
149184-21-4 sc-361142
sc-361142A
10 mg
50 mg
$195.00
$0.00
0
(1)
Flumazenil (Ro 15-1788)
Flumazenil (Ro 15-1788) is a benzodiazepine antagonist
78755-81-4 sc-200161
sc-200161A
20 mg
100 mg
$62.00
$259.00
10
(1)
(+/-)-Baclofen
(±)-Baclofen is a selective agonist of the GABAB receptor
1134-47-0 sc-200464
sc-200464A
1 g
5 g
$49.00
$243.00
0
(1)
GS 39783
GS 39783 is a positive modulator at GABAB receptors
39069-52-8 sc-203589
sc-203589A
10 mg
50 mg
$101.00
$575.00
0
(0)
SR 95531 Hydrobromide
SR 95531 Hydrobromide is a selective GABAA receptor antagonist
104104-50-9 sc-203701
sc-203701A
10 mg
50 mg
$145.00
$490.00
0
(1)
(+)-Bicuculline
(+)-Bicuculline is a GABA A receptor antagonist
485-49-4 sc-202498
sc-202498A
50 mg
250 mg
$54.00
$201.00
0
(1)
16alpha,17alpha-Epoxypregnenolone acetate
CAS: 34209-81-9, MF: C23H32O4, MW: 372.50
34209-81-9 sc-224978
5 g
$29.00
0
(0)
Thiomuscimol
Thiomuscimol is an analog used as a photoaffinity label for GABAA
62020-54-6 sc-213035
10 mg
$350.00
2
(1)
Isoguvacine HCl
Isoguvacine⋅HCl is an agonist of Gamma-amino butyric acid receptors
68547-97-7 sc-200451
sc-200451A
10 mg
50 mg
$25.00
$108.00
2
(0)
CGP 52432
CGP 52432 is A selective and effective GABAB receptor antagonist
139667-74-6 sc-361141
sc-361141A
10 mg
50 mg
$199.00
$825.00
0
(0)
Indiplon
Indiplon is a potent GABAAreceptor positive allosteric modulator
325715-02-4 sc-204011
sc-204011A
10 mg
50 mg
$129.00
$516.00
0
(0)
Phenylbenzene omega-phosphono-alpha-amino acid
Phenylbenzene ω-phosphono-α-amino acid is a selective strychnine-sensitive GlyR antagonist
sc-301540
10 mg
$286.00
1
(0)
16-Dehydropregnenolone acetate
CAS: 979-02-2, MF: C23H32O3, MW: 356.50, Purity: ≥98%
979-02-2 sc-224976
10 g
$238.00
0
(0)
(-)-Bicuculline methiodide
(−)-Bicuculline methiodide is a N-methylated derivative of the GABAA antagonist (+)-bicuculline
40709-69-1 sc-200485
50 mg
$142.00
5
(1)
R-(+)-Baclofen hydrochloride
R-(+)-Baclofen hydrochloride is a seelctive GABAB receptor agonist
63701-55-3 sc-203229
sc-203229A
10 mg
50 mg
$30.00
$117.00
0
(0)
SKF-89976A
SKF-89976A is a GABA transporter type 1 inhibitor
85375-15-1 sc-253567
10 mg
$80.00
0
(0)
TPMPA
TPMPA is TPMPA is a competitive, selective GABAC antagonist
182485-36-5 sc-204352
sc-204352A
10 mg
50 mg
$215.00
$750.00
1
(0)
5alpha-Pregnan-3beta-ol-20-one 3beta-acetate
CAS: 906-83-2, MF: C23H36O3, MW: 360.53, Purity: ≥98%
906-83-2 sc-233497
5 g
$215.00
0
(0)
Propybicyphat
Propybicyphat is a GABA-gated chloride channel blocker
51486-74-9 sc-301615
1 mg
$229.00
0
(0)
NCS-382 Sodium Salt
NCS-382 Sodium Salt is a γ-Hydroxybutyric acid antagonist
131733-92-1 sc-203444
sc-203444A
10 mg
50 mg
$82.00
$360.00
0
(0)
GABA
GABA is an inhibitory neurotransmitter in the CNS
56-12-2 sc-203053
sc-203053A
sc-203053B
sc-203053C
10 g
25 g
5 kg
10 kg
$40.00
$82.00
$390.00
$720.00
1
(1)
17alpha-Hydroxypregnenolone
17α-Hydroxypregnenolone is a C21 steroid and prohormone in the formation of DHEA
387-79-1 sc-223186
5 g
$446.00
1
(0)
Thiocolchicoside
Thiocolchicoside is a GABAA receptor antagonist
602-41-5 sc-202839
sc-202839A
1 mg
5 mg
$30.00
$120.00
0
(0)
Hispidulin
Hispidulin is a potent benzodiazepine (BZD) receptor ligand
1447-88-7 sc-203999
sc-203999A
sc-203999B
sc-203999C
10 mg
100 mg
500 mg
1 g
$245.00
$970.00
$2,945.00
$5,300.00
1
(0)
Pregnenolone sulfate sodium salt
Pregnenolone sulfate sodium salt is is a GABAA receptor antagonist
1852-38-6 sc-301609
50 mg
$60.00
0
(1)
Muscimol
Muscimol is a potent and specific GABAA receptor agonist/GABA analog
2763-96-4 sc-200460
sc-200460A
5 mg
25 mg
$96.00
$225.00
2
(1)
Valerenic acid
Valerenic acid is a positive allosteric modulator of the GABAA receptor
3569-10-6 sc-204377
sc-204377A
1 mg
10 mg
$53.00
$460.00
1
(1)
Chlormethiazole hydrochloride
Chlormethiazole hydrochloride is potentiates GABAA receptor function
6001-74-7 sc-203548
sc-203548A
10 mg
50 mg
$110.00
$385.00
0
(0)
Guvacine hydrochloride
Guvacine hydrochloride is inhibits GABA uptake
6027-91-4 sc-263347
25 mg
$93.00
0
(1)
Dihydroergotoxine mesylate
Dihydroergotoxine mesylate is binds with high affinity to GABAA receptor
8067-24-1 sc-203921
100 mg
$109.00
0
(0)
trans-4-Hydroxycrotonic acid
trans-4-Hydroxycrotonic acid is a compound that binds to the GHB receptor with higher affinity than GHB
24587-49-3 sc-203710
sc-203710A
10 mg
50 mg
$89.00
$510.00
0
(0)
TACA
TACA is a GABAA and GABAC agonist
38090-53-8 sc-203705
sc-203705A
10 mg
50 mg
$90.00
$290.00
0
(0)
Tracazolate hydrochloride
Tracazolate hydrochloride is a modulator of GABAA receptors
1135210-68-2 sc-203709
sc-203709A
10 mg
50 mg
$89.00
$359.00
0
(0)
Stiripentol
Stiripentol is an inhibitor of CYP1A2, CYP2C19 and CYP3A4
49763-96-4 sc-208402
100 mg
$300.00
0
(0)
(-)-Bicuculline methochloride
(−)-Bicuculline methochloride is a water-soluble GABAA antagonist
53552-05-9 sc-203528
sc-203528A
10 mg
50 mg
$109.00
$323.00
0
(0)
gamma-Acetylenic GABA
gamma-Acetylenic GABA is a GABA transaminase inhibitor
57659-38-8 sc-295002
sc-295002A
1 mg
5 mg
$200.00
$400.00
0
(0)
Gabaculine
Gabaculine is a conformationally constrained analog of GABA
59556-17-1 sc-200473
sc-200473A
sc-200473B
10 mg
50 mg
250 mg
$300.00
$850.00
$2,950.00
2
(1)
Vigabatrin
Vigabatrin is a selective GABA transaminase inhibitor
60643-86-9 sc-204382
sc-204382A
sc-204382B
sc-204382C
10 mg
50 mg
100 mg
1 g
$88.00
$359.00
$480.00
$700.00
1
(1)
THIP hydrochloride
THIP hydrochloride is a GABAA receptor agonist and GABAC receptor antagonist
64603-91-4 sc-204342
50 mg
$149.00
0
(0)
CL 218872
CL 218872 is a benzodiazepine agonist selective for α1 subunit-containing GABAA receptors
66548-69-4 sc-203552
sc-203552A
10 mg
50 mg
$85.00
$319.00
0
(0)
3-Methyl-GABA
3-Methyl-GABA is an activator of GABA aminotransferase
71424-95-8 sc-203471
sc-203471A
10 mg
50 mg
$119.00
$510.00
0
(0)
Nefiracetam
Nefiracetam is activator of L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems
77191-36-7 sc-205766
sc-205766A
100 mg
250 mg
$125.00
$140.00
0
(0)
DMCM hydrochloride
DMCM hydrochloride is a benzodiazepine inverse agonist
82499-00-1 sc-205295
sc-205295A
10 mg
50 mg
$190.00
$770.00
0
(0)
ZAPA sulfate
ZAPA sulfate is a selective potent GABAA receptor agonist
92138-10-8 sc-200471
sc-200471A
5 mg
25 mg
$71.00
$275.00
0
(0)
Topiramate
Topiramate is a GluR5 kainate receptor antagonist which also inhibits Nav channels, L-type Ca2+ channels, and carbonic anhydrase
97240-79-4 sc-204350
sc-204350A
10 mg
50 mg
$103.00
$355.00
0
(1)
Phaclofen
Phaclofen is a selective GABAB receptor antagonist
114012-12-3 sc-200462
sc-200462A
5 mg
25 mg
$91.00
$379.00
0
(0)
2-Hydroxysaclofen
2-Hydroxysaclofen is a selective GABAB antagonist
117354-64-0 sc-202011
sc-202011A
2.5 mg
10 mg
$199.00
$180.00
0
(0)
CGP 46381
CGP 46381 is a selective GABAB receptor antagonist
123691-14-5 sc-361140
sc-361140A
10 mg
50 mg
$175.00
$739.00
0
(0)
Saclofen
Saclofen is a selective GABAB antagonist
125464-42-8 sc-203252
10 mg
$175.00
0
(0)
SKF 97541
SK&F 97541 is a very potent GABAB agonist/GABAC antagonist
127729-35-5 sc-200469
sc-200469A
5 mg
25 mg
$101.00
$450.00
0
(0)
FGIN-1-43
FGIN-1-43 is a specific ligand for mitochondrial diazepam binding inhibitor receptor
145040-29-5 sc-203953
sc-203953A
10 mg
50 mg
$119.00
$510.00
0
(0)
Tiagabine Hydrochloride
Tiagabine Hydrochloride is an uptake inhibitor of GABA and also an anticonvulsant
145821-59-6 sc-208437
10 mg
$160.00
0
(0)
(S)-SNAP 5114
(S)-SNAP 5114 is a GABA uptake inhibitor that increases thalamic GABA levels
157604-55-2 sc-204257
sc-204257A
5 mg
25 mg
$115.00
$406.00
0
(0)
NNC 05-2090 hydrochloride
NNC 05-2090 hydrochloride is a GABA uptake inhibitor displaying selectivity for BGT-1 (mGAT-2) transporters
184845-43-0 sc-204131
sc-204131A
10 mg
50 mg
$214.00
$825.00
0
(0)
TB 21007
TB 21007 is a GABAA receptor inverse agonist
207306-50-1 sc-204322
sc-204322A
10 mg
50 mg
$169.00
$715.00
0
(0)
Etbicyphat
Etbicyphat is a synthetic, non-competitive GABA antagonist
1005-93-2 sc-294479
500 mg
$420.00
0
(0)
R-(+)-Baclofen (free base)
R-(+)-Baclofen (free base) is a selective GABAB receptor agonist
69308-37-8 sc-203228
sc-203228A
10 mg
50 mg
$50.00
$195.00
0
(0)
FrPbAII
FrPbAII is a GABA and glycine uptake inhibtor
sc-221630
5 mg
$450.00
0
(0)
6,2prime-Dihydroxyflavone
6,2′-Dihydroxyflavone is is a partial inverse agonist at GABAA receptors with a-subunit selectivity
sc-300048
5 mg
$119.00
0
(0)
β-Alanine
β-Alanine is an endogenous glycine agonist and GABA transporter inhibitor
107-95-9 sc-364682
sc-364682A
25 g
500 g
$30.00
$94.00
0
(0)
21-Acetoxypregnenolone
566-78-9 sc-231272
sc-231272A
1 g
25 g
$51.00
$1,080.00
0
(0)
16alpha,17alpha-Epoxypregnenolone
974-23-2 sc-223173
sc-223173A
5 g
10 g
$45.00
$83.00
0
(0)
Mebicyphat
Mebicyphat is a noncompetitive GABA antagonist
1449-89-4 sc-295376
500 mg
$395.00
0
(0)
SCS
SCS is potent and selective partial inhibitor of β1-containing GABAA receptors
3232-36-8 sc-203375
50 mg
$105.00
0
(0)
3alpha,12alpha-Dihydroxy-5beta-pregnan-20-one 3,12-diacetate
15991-93-2 sc-226347
50 mg
$50.00
0
(0)
16,17-Epoxy-21-acetoxypregnenolone
CAS: 28444-97-5, MF: C23H32O5, MW: 388.50
28444-97-5 sc-224977
1 g
$68.00
0
(0)
17alpha-Hydroxypregnenolone 3-acetate
CAS: 41906-06-3, MF: C23H34O4, MW: 374.51
41906-06-3 sc-224980
5 g
$175.00
0
(0)
CGP 13501
CGP 13501 is a positive allosteric modulator at GABAB receptors
56189-68-5 sc-203542
sc-203542A
10 mg
50 mg
$155.00
$645.00
0
(0)
CGP 7930
CGP 7930 is positive allosteric modulator of GABAB receptors
57717-80-3 sc-203543
sc-203543A
10 mg
50 mg
$148.00
$520.00
0
(0)
S(+)-gamma-Vinyl-GABA
S(+)-gamma-Vinyl-GABA is a selective ABAT (GABA transaminase) inhibitor
74046-07-4 sc-222279
sc-222279A
sc-222279B
sc-222279C
sc-222279D
5 mg
10 mg
50 mg
100 mg
250 mg
$440.00
$700.00
$1,683.00
$3,000.00
$5,000.00
0
(0)
ZK 93423 hydrochloride
ZK 93423 hydrochloride is a potent benzodiazepine agonist
83910-44-5 sc-204422
sc-204422A
10 mg
50 mg
$179.00
$750.00
0
(0)
SKF 89976A hydrochloride
SKF 89976A hydrochloride is a potent GABA uptake inhibitor
85375-85-5 sc-203266
sc-203266A
1 mg
10 mg
$30.00
$123.00
0
(0)
ZK 93426 hydrochloride
ZK 93426 hydrochloride is a elective and competitive benzodiazepine receptor antagonist
89592-45-0 sc-203727
sc-203727A
10 mg
50 mg
$169.00
$630.00
0
(0)
RO 15-4513
RO 15-4513 is a high affinty benzodiazepine ligand and GABAA antagonist
91917-65-6 sc-203683
10 mg
$138.00
0
(0)
RO 19-4603
RO 19-4603 is an agent that binds with high affinity to GABAA receptors
99632-94-7 sc-203684
sc-203684A
10 mg
50 mg
$125.00
$560.00
0
(0)
CI 966 hydrochloride
CI 966 hydrochloride is a selective inhibitor of GABA T-1
110283-66-4 sc-203891
sc-203891A
10 mg
50 mg
$169.00
$681.00
0
(0)
Loreclezole hydrochloride
Loreclezole hydrochloride is a subtype-selective GABAA receptor agonist
117857-45-1 sc-204061
sc-204061A
10 mg
50 mg
$195.00
$849.00
0
(0)
Ganaxolone
Ganaxolone is a potent stereoselective modulator of GABAA receptors
38398-32-2 sc-203586
sc-203586A
10 mg
50 mg
$129.00
$560.00
0
(1)
L-655,708
L-655,708 is a potent and selective inverse agonist for the benzodiazepine
130477-52-0 sc-204040
sc-204040A
5 mg
25 mg
$88.00
$263.00
0
(0)
rac BHFF
rac BHFF is a GABAB receptor positive allosteric modulator
123557-91-5 sc-204228
sc-204228A
5 mg
25 mg
$110.00
$420.00
0
(0)
CGP 36216
CGP 36216 is a GABAB selective antagonist
123691-29-2 sc-362724
sc-362724A
10 mg
50 mg
$155.00
$712.00
0
(0)
U 90042
U 90042 is a GABAA receptor ligand
134516-99-7 sc-204362
sc-204362A
10 mg
50 mg
$155.00
$620.00
0
(0)
U 93631
U 93631 is a GABAA receptor antagonist
152273-12-6 sc-204364
sc-204364A
10 mg
50 mg
$169.00
$715.00
0
(0)
Org 20599
Org 20599 is a positive allosteric modulator and agonist of GABA receptors
156685-94-8 sc-204150
sc-204150A
10 mg
50 mg
$185.00
$781.00
0
(0)
Thiomuscimol Biotin
sc-507142
sc-507142A
2.5 mg
5 mg
$950.00
$1,800.00
0
(0)
Pentylenetetrazole
Pentylenetetrazole is a useful biochemical in neurotransmitter studies
54-95-5 sc-203345
sc-203345A
5 g
25 g
$40.00
$65.00
2
(1)
U 89843A
U 89843A is a positive allosteric modulator of GABAA receptors
157013-85-9 sc-204361
sc-204361A
10 mg
50 mg
$125.00
$525.00
0
(0)
SB 205384
SB 205384 is a GABAA receptor modulator
160296-13-9 sc-204263
sc-204263A
10 mg
50 mg
$195.00
$825.00
0
(1)
Cloflubicyne
Cloflubicyne is a potent non-competitive GABA antagonist
224790-70-9 sc-300382
1 mg
$260.00
0
(0)
5-Nitro-alpha-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide
TCS 1205 is a GABAA α2 agonist
355022-97-8 sc-358561
sc-358561A
10 mg
50 mg
$135.00
$595.00
0
(0)
DS2
DS2 is a positive allosteric modulator of δ-subunit containing GABAA receptors
374084-31-8 sc-294421
sc-294421A
10 mg
25 mg
$170.00
$715.00
0
(0)
17-PA
17-PA is an antagonist of neurosteroid GABA potentiation
694438-95-4 sc-361075
sc-361075A
10 mg
50 mg
$239.00
$999.00
0
(0)
AA 29504
AA 29504 is a positive allosteric modulator of GABAA receptors
945828-50-2 sc-361096
sc-361096A
5 mg
25 mg
$83.00
$350.00
0
(0)
Dansyl-gamma-Amino-n-Butyric Acid Cyclohexylammonium Salt
76563-43-4 sc-294267
sc-294267A
100 mg
250 mg
$30.00
$57.00
0
(0)

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