Santa Cruz Biotechnology offers an expansive library of transfected lysates that overexpress GTP/GDP binding proteins. Guanosine triphosphate (GTP)/guanosine diphosphate (GDP)-binding proteins have a different conformation depending on whether they are bound to GTP or GDP. GTP usually stabilizes the active conformation of these proteins, and hydrolysis of the bound GTP to GDP + Pi usually causes the protein to become inactive. Reactivation occurs when the bound GDP is released in exchange for GTP. Heterotrimeric G-proteins, short for guanine nucleotide binding proteins, are a family of GTP-binding proteins that play a role in second messenger cascades. Members of the family of small GTP-binding proteins have a broad range of functions, most of which pertain to cell communication and signaling cascades. Examples of such important GTP/GDP binding proteins include Rac, Rho, Ras, Vav and C3G. Transfected lysates that express GTP/GDP binding proteins offer a reliable means to evaluate antibody quality and serve as excellent positive controls for experiments involving antibodies.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.