1700007G11Rik Activators
Cilia- and Flagella-Associated Protein 299 activators comprise a diverse set of chemical compounds that enhance the protein's activity through various cellular mechanisms. Forskolin and Isoproterenol, by stimulating adenylate cyclase, increase intracellular cAMP levels, which subsequently activate PKA. This activation cascade can lead to phosphorylation events that enhance Cilia- and Flagella-Associated Protein 299 functions, particularly in ciliary motility and signaling. Similar cAMP-elevating effects are achieved through the inhibition of phosphodiesterases by compounds like IBMX, Rolipram, and Cilostamide, which prevent cAMP breakdown and further promote PKA-mediated processes that could be essential for Cilia- and Flagella-Associated Protein 299 activity. The functionality of CFAP299 is further influenced by compounds that modulate the concentration of cyclic nucleotides within the cell. For example, Sildenafil citrate and Zaprinast are PDE5 inhibitors that may elevate cGMP levels, which have been implicated in ciliary motility, suggesting an indirect method of CFAP299 activation.
PDE inhibitors such as Cilostazol and Milrinone increase cAMP, which could lead to improved ciliary function, potentially benefiting CFAP299's role in these structures. Non-selective PDE inhibitors like IBMXand Aminophylline, as well as Pentoxifylline, also contribute to the enhancement of CFAP299 by raising cyclic nucleotide levels, thereby influencing the signaling pathways that govern ciliary motion and assembly. Notably, Anagrelide's inhibition of PDE3 and subsequent increase in cAMP may impact the process of ciliogenesis, providing a conducive environment for CFAP299 to function optimally within the ciliary architecture. Collectively, these CFAP299 Activators, by targeting specific cellular signaling mechanisms, facilitate the enhancement of CFAP299-mediated functions linked to the dynamic and structural aspects of cilia and flagella without invoking direct activation or upregulation of CFAP299 itself.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits glycogen synthase kinase 3 (GSK-3). Inhibition of GSK-3 has been shown to stabilize microtubules and may promote the assembly and stability of cilia, potentially enhancing the function of Cilia- and flagella-associated protein 299 by contributing to the structural integrity of cilia and flagella. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid influences cellular differentiation and proliferation. It has been implicated in the regulation of ciliogenesis through signaling pathways that involve the modulation of gene expression related to cilia formation and maintenance. This can indirectly enhance Cilia- and flagella-associated protein 299 activity by increasing the need for cilia-associated proteins in newly formed cilia. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate (EGCG) is known to inhibit several protein kinases, which might lead to altered ciliary signaling dynamics. This can indirectly enhance the activity of Cilia- and flagella-associated protein 299 by modifying the phosphorylation status of proteins involved in ciliogenesis and cilia function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram selectively inhibits phosphodiesterase 4 (PDE4), leading to an accumulation of cAMP within the cell. This elevation in cAMP can enhance PKA activity, which may then phosphorylate substrates involved in cilia maintenance and function, indirectly augmenting the activity of Cilia- and flagella-associated protein 299. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine is a polyamine known to stabilize microtubules, which are essential components of cilia and flagella. Through the stabilization of microtubules, spermidine can indirectly enhance the activity of Cilia- and flagella-associated protein 299 by supporting the structural framework necessary for proper ciliary function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which is crucial for the maintenance of cilia structure. By stabilizing microtubules, Paclitaxel can enhance the functional activity of Cilia- and flagella-associated protein 299 by maintaining ciliary integrity and potentially increasing ciliary length and function. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine is a calmodulin antagonist that can influence calcium signaling. Since calcium signaling is important for cilia beat frequency and coordination, Chlorpromazine might enhance the activity of Cilia- and flagella-associated protein 299 by affecting the beat frequency and potentially cilia-mediated signaling. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide acts as an inhibitor of sirtuins, which are NAD+-dependent deacetylases. Sirtuin inhibition has been associated with the modulation of acetylation levels of microtubules. Through the increased acetylation of microtubules, Nicotinamide may enhance the functional activity of Cilia- and flagella-associated protein 299 by promoting microtubule stability in cilia. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Chloride (ZnCl2) can function as a stabilizer of microtubule growth and can influence microtubule dynamics. The presence of Zinc can enhance the activity of Cilia- and flagella-associated protein 299 by promoting the assembly and stability of cilia through the stabilization of microtubules. | ||||||