Date published: 2026-4-24

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11 beta-HSD Inhibitors

Santa Cruz Biotechnology now offers a broad range of 11 beta-HSD Inhibitors for use in various applications. 11 beta-HSD inhibitors are specialized compounds that target and inhibit the enzyme 11β-hydroxysteroid dehydrogenase, which plays a crucial role in the metabolism of glucocorticoids by converting active cortisol to its inactive form, cortisone, and vice versa. These inhibitors are essential tools in scientific research for studying the regulation of glucocorticoid action at the tissue level, providing insights into the enzyme's role in various physiological and pathological processes, such as metabolism, stress response, and inflammation. Researchers utilize 11 beta-HSD inhibitors to investigate the local modulation of glucocorticoid activity and its implications for metabolic diseases, endocrine disorders, and the development of obesity. These inhibitors are also valuable in exploring the mechanisms underlying the enzyme's contribution to cellular differentiation, proliferation, and apoptosis. The availability of high-purity 11 beta-HSD inhibitors from Santa Cruz Biotechnology ensures that experiments can be conducted with high precision and reproducibility, leading to reliable data that advance our understanding of glucocorticoid regulation. By offering a comprehensive selection of these inhibitors, Santa Cruz Biotechnology supports the scientific community in their quest to uncover the complexities of glucocorticoid metabolism and develop new experimental models and methodologies. View detailed information on our available 11 beta-HSD Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Carbenoxolone disodium

7421-40-1sc-203868
sc-203868A
sc-203868B
sc-203868C
1 g
5 g
10 g
25 g
$46.00
$201.00
$358.00
$774.00
1
(3)

Carbenoxolone disodium acts as a selective inhibitor of 11 beta-hydroxysteroid dehydrogenase type 1, modulating cortisol metabolism. Its unique structure allows for specific binding interactions with the enzyme's active site, altering the kinetics of steroid conversion. This compound exhibits a distinct ability to influence glucocorticoid signaling pathways, potentially impacting metabolic processes. Its interactions can lead to nuanced effects on cellular responses to stress and inflammation.

HSD Inhibitor 23

868604-75-5sc-203076
1 mg
$300.00
(0)

HSD Inhibitor 23 functions as a potent modulator of 11 beta-hydroxysteroid dehydrogenase, characterized by its ability to selectively disrupt the enzyme's catalytic activity. Its unique molecular architecture facilitates specific interactions with key amino acid residues, enhancing binding affinity and altering reaction kinetics. This compound exhibits distinctive effects on steroid hormone regulation, influencing metabolic pathways and cellular signaling cascades, thereby affecting physiological responses to various stimuli.

Glycyrrhizic acid

1405-86-3sc-279186
sc-279186A
1 g
25 g
$57.00
$333.00
7
(0)

Glycyrrhizic acid acts as a selective inhibitor of 11 beta-hydroxysteroid dehydrogenase, showcasing a unique ability to stabilize enzyme conformation through specific hydrogen bonding and hydrophobic interactions. This compound alters the enzyme's substrate specificity, leading to a shift in steroid metabolism. Its structural features enable it to modulate the kinetics of enzymatic reactions, impacting the balance of glucocorticoids and influencing downstream signaling pathways.