Topo Inhibitors

Santa Cruz Biotechnology now offers a broad range of Topo Inhibitors. DNA topoisomerase I and II (Topo I and Topo II) are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Topo Inhibitors offered by Santa Cruz inhibit Topo and, in some cases, other DNA replication and recombination related proteins. View detailed Topo Inhibitor specifications, including Topo Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.

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PRODUCT NAME/Application CAS Catalog # QUANTITY Price Citations RATING
Gatifloxacin
Gatifloxacin is a fluoroquinolone antibiotic and inhibitor of bacterial Topo II (topoismerase II)
112811-59-3 sc-204762
sc-204762A
1 g
5 g
$60.00
$260.00
13
(1)
Rufloxacin Hydrochloride
Rufloxacin Hydrochloride is a fluoroquinolone antibacterial
106017-08-7 sc-202326
sc-202326A
50 mg
250 mg
$50.00
$200.00
1
(1)
Tosufloxacin tosylate
Tosufloxacin tosylate is an antibacterial agent that inhibits bacterial DNA gyrase inhibitor
115964-29-9 sc-204920
sc-204920A
250 mg
1 g
$98.00
$294.00
1
(2)
9Z,11E,13E-Octadecatrienoic Acid ethyl ester
9Z,11E,13E-Octadecatrienoic Acid ethyl ester is a conjugated polyunsaturated fatty acid
42021-86-3 sc-205198
sc-205198A
1 mg
100 mg
$90.00
$220.00
0
(0)
Doxorubicin hydrochloride
Doxorubicin hydrochloride is an anthracycline antitumor antibiotic topoisomerase II inhibitor, DNA intercalator and powerful cytotoxic agent.
25316-40-9 sc-200923
sc-200923B
sc-200923A
sc-200923C
sc-200923D
5 mg
10 mg
25 mg
100 mg
250 mg
$77.00
$140.00
$309.00
$280.00
$500.00
18
(1)
Camptothecin
Camptothecin is a reversible Mitochondrial Topo I inhibitor shown to exhibit antitumor activity
7689-03-4 sc-200871
sc-200871B
sc-200871A
50 mg
100 mg
250 mg
$46.00
$80.00
$168.00
15
(2)
Suramin sodium
Suramin sodium is a non-selective P2 purinergic antagonist, blocking G protein coupling and inhibiting PDGF, EGF, TGFb, SIRT1 and SIRT5.
129-46-4 sc-200833
sc-200833A
sc-200833B
50 mg
250 mg
1 g
$50.00
$158.00
$540.00
6
(2)
SN 38
SN 38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11)
86639-52-3 sc-203697
sc-203697A
sc-203697B
10 mg
50 mg
500 mg
$109.00
$323.00
$860.00
12
(3)
beta-Lapachone
β-Lapachone is a selective DNA topoisomerase I inhibitor
4707-32-8 sc-200875
sc-200875A
5 mg
25 mg
$77.00
$324.00
6
(1)
Etoposide (VP-16)
Etoposide (VP-16) is inhibits DNA synthesis via topoisomerase II inhibition
33419-42-0 sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$25.00
$154.00
$325.00
28
(1)
Mitoxantrone Dihydrochloride
Mitoxantrone Dihydrochloride is induces DNA damage by intercalating into DNA and inhibiting Topo II
70476-82-3 sc-203136
sc-203136A
sc-203136B
sc-203136C
10 mg
50 mg
100 mg
1 g
$31.00
$57.00
$114.00
$760.00
4
(1)
Celastrol, Celastrus scandens
Celastrol, Celastrus scandens is an antiproliferative, antipreroxidative, and inhibits Topo II
34157-83-0 sc-202534
10 mg
$152.00
5
(1)
Epirubicin Hydrochloride
Epirubicin Hydrochloride is a cell-permeable Topo II inhibitor
56390-09-1 sc-203041
sc-203041A
sc-203041B
5 mg
25 mg
100 mg
$147.00
$280.00
$528.00
0
(1)
Topotecan Hydrochloride
Topotecan Hydrochloride is a water-soluble inhibitor of DNA Topo I
119413-54-6 sc-204919
sc-204919A
1 mg
5 mg
$34.00
$93.00
0
(1)
Ellipticine
Ellipticine is a DNA intercalating inhibitor of Topo II
519-23-3 sc-200878
sc-200878A
10 mg
50 mg
$104.00
$430.00
4
(1)
Moxifloxacin Hydrochloride
Moxifloxacin Hydrochloride is an antibacterial agent that inhibits the activities of Topo II (DNA gyrase) and topoisomerase IV
186826-86-8 sc-205758
sc-205758A
100 mg
500 mg
$116.00
$440.00
10
(1)
(S)-10-Hydroxycamptothecin
(S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase I
19685-09-7 sc-205614
sc-205614A
25 mg
100 mg
$58.00
$165.00
2
(1)
SN-38-d3
SN-38-d3 is A metabolite of Irinotecan, a DNA topoisomerase inhibitor.
718612-49-8 sc-208392
sc-208392B
sc-208392A
sc-208392C
1 mg
2.5 mg
5 mg
10 mg
$700.00
$1,540.00
$2,900.00
$2,765.00
0
(0)
Pirarubicin
Pirarubicin is an anti-neoplastic and inhibitor of Topo II
72496-41-4 sc-205810
sc-205810A
5 mg
10 mg
$170.00
$300.00
0
(0)
7-Ethyl Camptothecin
7-Ethyl Camptothecin is an anti-cancer agent and Topo I inhibitor
78287-27-1 sc-207171
10 mg
$188.00
0
(0)
Amonafide
Amonafide is a DNA intercalator and topoisomerase II inhibitor
69408-81-7 sc-207283
10 mg
$216.00
0
(0)
11-Ethyl Camptothecin
11-Ethyl Camptothecin is a substituted Topo I inhibitor
185807-29-8 sc-213584
10 mg
$31,500.00
0
(0)
7-Ethyl-d3-camptothecin
7-Ethyl-d3-camptothecin is a deuterium labeled Topo I inhibitor
1217626-02-2 sc-217437
1 mg
$450.00
0
(0)
Amonafide-d6
Amonafide-d6 is a Topo II inhibitor and an antitumor agent
69408-81-7 (unlabeled) sc-217636
1 mg
$280.00
0
(0)
Ofloxacin
Ofloxacin is an antibacterial Topo II and Topo IV inhibitor
82419-36-1 sc-219475
10 g
$221.00
1
(0)
(R)-7-Ethyl Camptothecin
(R)-7-Ethyl Camptothecin is a R-Camptothecin derivative and Topo I inhibitor
1217633-65-2 sc-219741
1 mg
$280.00
0
(0)
Genistein-2prime,3prime,5prime,6prime-d4
Genistein-2′,3′,5′,6′-d4 is a protein kinase inhibitor
187960-08-3 sc-280728
1 mg
$280.00
0
(0)
Dexrazoxane
Dexrazoxane is an inhibitor of Topo II
24584-09-6 sc-252669
5 mg
$70.00
1
(1)
Razoxane
Razoxane is an inhibitor of Topo II
21416-67-1 sc-253425
sc-253425A
5 mg
25 mg
$72.00
$288.00
0
(0)
(+)-Irinotecan
(+)-Irinotecan is a Topo I inhibitor
97682-44-5 sc-269253
10 mg
$60.00
0
(1)
Epirubicin
Epirubicin is a cell permeable Topo II inhibitor
56420-45-2 sc-279016
25 mg
$450.00
0
(0)
1,4-Naphthoquinone
1,4-Naphthoquinone is a chemical studied as a potential inhibitor of MAO (monoamine oxidase) and Topo (DNA topoisomerase) activities as well as acetyltra
130-15-4 sc-237768
sc-237768A
100 g
250 g
$34.00
$40.00
0
(0)
trovafloxacin mesylate
trovafloxacin mesylate is a fluoroquinolone antibiotic and Topo IV inhibitor
147059-75-4 sc-280171
sc-280171A
sc-280171B
100 mg
10 mg
50 mg
$1,200.00
$155.00
$490.00
0
(0)
Genistein-2prime,6prime-d2
Genistein-2′,6′-d2 is a labeled form of genistein
315204-48-9 sc-280729
1 mg
$220.00
0
(0)
Irinotecan Carboxylate Sodium Salt
Irinotecan Carboxylate Sodium Salt is a carboxylated Topo I inhibitor
sc-280848
5 mg
$280.00
0
(0)
Irinotecan-d10 Hydrochloride
Irinotecan-d10 Hydrochloride is a deuterated DNA Topo I inhibitor
718612-62-5 sc-280849
sc-280849A
1 mg
10 mg
$250.00
$2,000.00
7
(1)
Sodium Camptothecin
Sodium Camptothecin is the salt form of Camptothecin
25387-67-1 sc-338592
1 g
$700.00
0
(0)
Genistein
Genistein is a highly specific inhibitor of protein tyrosine kinase (PTK)
446-72-0 sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$25.00
$90.00
$118.00
$304.00
$490.00
$890.00
$1,785.00
23
(1)
Irinotecan Labeled d10
Irinotecan Labeled d10 is a deuterated DNA Topo I inhibitor
97682-44-5 (unlabeled) sc-353632
10 mg
$2,540.00
1
(0)
Temafloxacin Hydrochloride
Temafloxacin Hydrochloride is a fluoroquinolone antibiotic
105784-61-0 sc-475068
25 mg
$395.00
0
(0)
Topotecan Hydrochloride Labeled d6
Topotecan Hydrochloride Labeled d6 is an isotope labeled Topo I inhibitor
119413-54-6 (unlabeled) sc-356167
10 mg
$2,000.00
0
(0)
BNS-22
BNS-22 is a potent 2H-chromen-2-one small molecule inhibitor of Topo II
1151668-24-4 sc-364676
10 mg
$193.00
0
(0)

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