epitope mapping within an internal region of Josephin-1 of human origin
recommended for detection of Josephin-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine and avian
Josephin-1 Background Information Josephin-1, also known as JOSD1 (josephin domain containing 1), is a 202 amino acid protein that contains one josephin domain and is encoded by a gene that maps to human chromosome 22. Chromosome 22 houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.
Josephin-1 (K-13)
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Josephin-1 (K-13): sc-86154. Western blot analysis of Josephin-1 expression in non-transfected: sc-110760 (A) and mouse Josephin-1 transfected: sc-110755 (B) 293 whole cell lysates.
