GC-1 Background Information GC-1, also known as OLFM4 (olfactomedin-4) or GW112, is a 510 amino acid protein that is secreted into extracellular space and contains one olfactomedin-like domain. Expressed at high levels in prostate, colon and small intestine, with lower levels in bone marrow and stomach tissue, GC-1 exists as a homomultimer that functions as an anti-apoptotic factor that promotes cell growth and proliferation. Specifically functioning to assist in the S to G2/M phase transition and to facilitate cell adhesion, GC-1 interacts with Grim19 and plays an important role in the pathogenesis of pancreatic, stomach and colon cancer. The gene encoding GC-1 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome.
