Bak (G-23) 抗体: sc-832

Bak Background Information
The Bcl-2 family of proteins is characterized by its ability to modulate cell death (apoptosis) under a broad range of physiologic conditions (1,2). Bcl-2 and several related proteins function to inhibit apoptosis (3-5), while other members of the Bcl-2 family, such as Bax, accelerate death under various conditions (6,7). One member of the Bcl-2 family, designated Bak, functions primarily to enhance apoptotic cell death following appropriate activating signals (1,2) and, in addition, counteracts the protection from apoptosis provided by Bcl-2 (1,2). Expression of Bak is widespread in a broad range of cells, including various long-lived, terminally differentiated cell types, suggesting that its cell-death-inducing activity is broadly distributed and that the regulation of inhibitors of apoptosis may represent an important determinant of tissue-specific modulation of apoptosis (1,2).