FLVCR Background Information FLVCR is a 555 amino acid protein encoded by the human gene FLVCR. It is a multi-pass membrane bound protein that belongs to the major facilitator superfamily, Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family. FLVCR is responsible for the exportation of cytoplasmic heme groups. It is believed that it may protect developing erythroid cells from heme toxicity. Expression of FLVCR in cells will cause susceptibility to FeLV-C (Feline leukemia virus subgroup C) in vitro. FLVCR is found in all hematopoietic tissues, including peripheral blood lymphocytes and fetal liver, and some expression is found in pancreas and kidney. It is down-regulated in haemopoietic progenitor cells undergoing differentiation and hemoglobinization.
