epitope mapping within an internal region of PDE1C of human origin
recommended for detection of PDE1C of h and r origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
PDE1C Background Information Phosphodiesterases (PDEs, also designated cyclic nucleotide phosphodiesterase) are important for the downregulation of intracellular levels of the second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). The PDE1 family are calmodulin-dependent (CaM-PDE) proteins that undergo stimulation through a calcium-calmodulin complex and function to hydrolyze cAMP to 5'AMP and cGMP to 5'GMP. PDE1C (phosphodiesterase 1C), also known as HCAM3, is a widely expressed protein that has a high affinity for both cAMP and cGMP. Two isoforms, designated PDE1C1 and PDE1C2, exist due to alternative splicing at the C-terminus. While both isoforms are expressed in low levels throughout the body, PDE1C2 is expressed predominately in the brain and heart, while PDE1C1 is expressed predominately in the brain, heart and lung.
PDE1C (T-17)
点击使图像放大
PDE1C (T-17): sc-54939. Western blot analysis of PDE1C expression in 293T whole cell lysate.
PDE1C (T-17): sc-54939. Western blot analysis of PDE1C expression in non-transfected: sc-110760 (A) and human PDE1C transfected: sc-158826 (B) 293 whole cell lysates.
