HLA-DRβ Antibody (TAL 14.1): sc-53316

HLA-DRβ Antibody (TAL 14.1) is a mouse monoclonal IgG2a antibody that detects HLA-DRβ in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). HLA-DRβ is a critical component of the major histocompatibility complex (MHC) class II molecules, which are essential for the adaptive immune response as they present processed antigens to CD4+ T helper cells. The proper functioning of HLA-DRβ is vital for the immune system′s ability to recognize and respond to pathogens, as HLA-DRβ facilitates the presentation of extracellular antigens, thereby influencing T cell activation and differentiation. Additionally, HLA-DRβ is located on the surface of antigen-presenting cells, such as B cells and dendritic cells, where HLA-DRβ plays a pivotal role in initiating immune responses. The expression of HLA-DRβ is tightly regulated and can be influenced by various factors, including cytokines and the presence of specific pathogens, making HLA-DRβ a key player in immune regulation and a potential biomarker for autoimmune diseases and infections. HLA-DRβ also undergoes post-translational modifications, such as glycosylation, which can affect stability, antigen presentation efficiency, and interactions with T cell receptors, further underscoring HLA-DRβ′s importance in immune system functionality. Anti-HLA-DRβ antibody (TAL 14.1) is an invaluable tool for researchers studying immune responses, autoimmune diseases, and the intricate mechanisms of antigen presentation.

The preferred HLA-DRβ antibody is HLA-DRβ Antibody (DA2): sc-53314.