epitope mapping within an internal region of kpm of human origin
recommended for detection of kpm of human and, to a lesser extent, mouse and rat origin by WB, IF and ELISA; also reactive with additional species, including equine, canine and bovine
kpm Background Information The human protein kinase kpm belongs to a subfamily of serine/threonine protein kinases, which includes the Drosophila tumor suppressor protein warts/lats (large tumor suppressor) (1). Among these, kpm is most homologous to, but distinct from, the human homolog LATS1 (1-4). Human LATS1 binds to Cdc2 in early mitosis and appears to negatively regulate the kinase activity of Cdc2 (5). The kpm protein is expressed relatively constantly throughout the cell cycle and undergoes significant phosphorylation at mitotic phase (1). Kpm plays a role in cell cycle progression during mitosis, and its deletion or dysfunction might be involved in certain types of human cancers (1).
