Doxycycline Hyclate (CAS 24390-14-5)
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Doxycycline Hyclate, also called doxycycline, is an antimicrobial tetracycline that acts as an inhibitor of a wide range of matrix metalloproteinases. It has been observed to significantly decrease the levels and activity of metalloproteinase-9 (MMP-9) in corneal erosion studies. Rheumatoid arthriitis studies indicate that Doxycycline Hyclate can block the degradation of type II collagen, and not type I collagen, as well as down regulate the expression levels and activity of MMP-8. Reports suggest that Doxycycline Hyclate blocks collagen activity and in smooth muscle studies increases smooth muscle cell adhesion, and changes the reorganization of fibrillar collagen matrices and cell migration. Additionally, Doxycycline Hyclate has been observed to alter the expression of apicoplast genes in Plasmodium falciparum, and inhibit tissue formation in rat tissue studies. Doxycycline Hyclate is also known as Doxycycline hydrochloride hemiethanolate hemihydrate, Atridox, α-6-Deoxy-5-hydroxytetracycline, and (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide hydrochloride hemiethanolate hemihydrate.
Doxycycline Hyclate (CAS 24390-14-5) References
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- Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. | Dahl, EL., et al. 2006. Antimicrob Agents Chemother. 50: 3124-31. PMID: 16940111
- The use and safety of doxycycline hyclate and other second-generation tetracyclines. | Sloan, B. and Scheinfeld, N. 2008. Expert Opin Drug Saf. 7: 571-7. PMID: 18759709
- Biowaiver monographs for immediate release solid oral dosage forms: Doxycycline hyclate. | Jantratid, E., et al. 2010. J Pharm Sci. 99: 1639-53. PMID: 19798752
- Development of doxycycline hyclate suppositories and pharmacokinetic study in rabbits. | Christ, AP., et al. 2020. Eur J Pharm Sci. 142: 105141. PMID: 31706017
- Tailored Doxycycline Hyclate Loaded In Situ Gel for the Treatment of Periodontitis: Optimization, In Vitro Characterization, and Antimicrobial Studies. | Ranch, KM., et al. 2021. AAPS PharmSciTech. 22: 77. PMID: 33595740
- Doxycycline Hyclate Modulates Antioxidant Defenses, Matrix Metalloproteinases, and COX-2 Activity Accelerating Skin Wound Healing by Secondary Intention in Rats. | Altoé, LS., et al. 2021. Oxid Med Cell Longev. 2021: 4681041. PMID: 33959214
- Doxycycline hyclate-loaded in situ forming gels composed from bleached shellac, Ethocel, and Eudragit RS for periodontal pocket delivery. | Senarat, S., et al. 2021. Saudi Pharm J. 29: 252-263. PMID: 33981174
- Niosome-encapsulated Doxycycline Hyclate for Potentiation of Acne Therapy: Formulation and Characterization. | Kashani-Asadi-Jafari, F. and Hadjizadeh, A. 2022. Pharm Nanotechnol. 10: 56-68. PMID: 35209832
- An efficacy trial of doxycycline chemoprophylaxis against leptospirosis. | Takafuji, ET., et al. 1984. N Engl J Med. 310: 497-500. PMID: 6363930
- Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline. | Hanemaaijer, R., et al. 1997. J Biol Chem. 272: 31504-9. PMID: 9395486
- Doxycycline Hyclate | Reema S. Patel and Mayur Parmar. 2023. Statpearls.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Doxycycline Hyclate, 100 mg | sc-204734B | 100 mg | $27.00 | |||
Doxycycline Hyclate, 1 g | sc-204734 | 1 g | $50.00 | |||
Doxycycline Hyclate, 5 g | sc-204734A | 5 g | $105.00 | |||
Doxycycline Hyclate, 25 g | sc-204734C | 25 g | $194.00 |