SURF-1 Antibody (E-7): sc-137037
- SURF-1 Antibody (E-7) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 81-250 mapping near the C-terminus of SURF-1 of human origin
- recommended for detection of SURF-1 of human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for ChIP application (sc-137037 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SURF-1 Antibody (E-7) for WB and IHC(P) applications. These reagents are now offered in bundles with SURF-1 Antibody (E-7) (see ordering information below).
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SURF-1 Antibody (E-7) is a mouse monoclonal IgG2b light chain antibody that detects SURF-1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SURF-1 plays a crucial role in the assembly of complex IV (cytochrome c oxidase) of the mitochondrial respiratory chain, which is essential for cellular respiration and energy production. Located in the inner mitochondrial membrane, SURF-1 is integral to the proper functioning of mitochondria, and mutations in the SURF-1 gene can lead to severe consequences, such as cytochrome c oxidase complex IV deficiency. This deficiency is associated with Leigh syndrome, a devastating neurological disorder characterized by rapid progression of encephalopathy and necrotic lesions in subcortical brain regions. The impact of SURF-1 mutations extends beyond neurological symptoms, as mutations are also linked to significant deficits in muscle strength and motor performance, particularly affecting skeletal muscle and liver function. Furthermore, individuals with SURF-1 mutations often exhibit morphological abnormalities in the heart, brain, and skeletal muscle, underscoring SURF-1′s critical role in maintaining mitochondrial integrity and overall cellular health.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SURF-1 Antibody (E-7) | sc-137037 | 200 µg/ml | $322.00 | |||
SURF-1 Antibody (E-7): m-IgG Fc BP-HRP Bundle | sc-537394 | 200 µg Ab; 10 µg BP | $361.00 | |||
SURF-1 Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-534648 | 200 µg Ab; 40 µg BP | $361.00 | |||
SURF-1 Antibody (E-7): m-IgG2b BP-HRP Bundle | sc-549865 | 200 µg Ab; 10 µg BP | $361.00 | |||
SURF-1 Antibody (E-7) X | sc-137037 X | 200 µg/0.1 ml | $322.00 |