epitope mapping near the C-terminus of TAB2 of human origin
recommended for detection of TAB2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and avian
TAB2 Background Information The TAK1 binding proteins, TAB1, TAB2 and TAB3, interact with the MAPKKK TAK1 in response to various stimuli. TAB1 activates TAK1 in TGF∫ mediated signaling. TAB1 also plays a central role in a p38å activation pathway that is independent of MAPKK. In response to proinflammatory signals, TAB2 complexes with TRAF6 and TAK1, leading to translocation of the complex from the membrane to the cytosol and the subsequent activation of TAK1. When overexpressed, TAB3 activates both NFkB and AP-1 transcription factors. In response to TNFå or IL-1, TAK1 complexes with TAB1 and TAB2 or with TAB1 and TAB3 to yield two distinct complexes.
TAB2 (K-20): sc-11851. Immunofluorescence staining of methanol-fixed A-431 cells (A) and immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tumor (B) showing cytoplasmic staining.
TAB2 (K-20): sc-11851. Western blot analysis of TAB2 expression in A-431 whole cell lysate.
TAB2 (K-20): sc-11851. Western blot analysis of TAB2 expression in non-transfected: sc-117752 (A) and mouse TAB2 transfected: sc-123889 (B) 293T whole cell lysates.
