KCNC4 Background Information KCNC4 (potassium voltage-gated channel, Shaw-related subfamily, member 4), also known as KV3.4 or KSHIIIC, is a 635 amino acid multi-pass membrane protein that belongs to the shaw subfamily of potassium channel proteins. Existing as either a homotetramer or as a heterotetramer with other potassium channel proteins, KCNC4 functions to mediate the voltage-dependent potassium ion permeability of excitable membranes, specifically by forming a channel through which potassium ions may pass in an electrochemical gradient-dependent manner. KCNC4, which is thought to influence neuronal excitability, is subject to phosphorylation on serine residues, an event which inhibits the rapid closure of potassium channels. Multiple isoforms of KCNC4 exist due to alternative splicing events.
