Aldehyde dehydrogenase 1-L1/ALDH1L1 Antibody (YY8): sc-100497

ALDH1L1 Antibody (YY8) is a mouse monoclonal IgG3 kappa light chain antibody that detects ALDH1L1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-ALDH1L1 antibody (YY8) is available as the non-conjugated format. ALDH1L1, also known as FTHFD or 10-formyltetrahydrofolate dehydrogenase, plays a crucial role in cellular metabolism by catalyzing the conversion of 10-formyltetrahydrofolate to tetrahydrofolate, a vital cofactor in the synthesis of nucleotides and amino acids. This enzymatic activity helps regulate cellular levels of tetrahydrofolate, which is essential for DNA synthesis and repair, thereby influencing cell proliferation and growth. ALDH1L1 is developmentally regulated in the cerebellum, indicating potential involvement in neurodevelopmental processes. ALDH1L1 overexpression has been shown to restrict cell proliferation in vitro, suggesting a tumor suppressor role in certain contexts. With diverse applications and significant biological implications, ALDH1L1 monoclonal antibody (YY8) serves as an invaluable tool for researchers studying metabolic pathways, neurodevelopment, and cellular growth regulation.

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Aldehyde dehydrogenase 1-L1/ALDH1L1 Antibody (YY8) References:

1. Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism.  |  Vasiliou, V., et al. 2000. Chem Biol Interact. 129: 1-19. PMID: 11154732
2. Human aldehyde dehydrogenases: potential pathological, pharmacological, and toxicological impact.  |  Sládek, NE. 2003. J Biochem Mol Toxicol. 17: 7-23. PMID: 12616643
3. The folate metabolic enzyme ALDH1L1 is restricted to the midline of the early CNS, suggesting a role in human neural tube defects.  |  Anthony, TE. and Heintz, N. 2007. J Comp Neurol. 500: 368-83. PMID: 17111379
4. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics.  |  Strolin Benedetti, M., et al. 2006. Expert Opin Drug Metab Toxicol. 2: 895-921. PMID: 17125408
5. Association of polymorphisms in one-carbon metabolism genes and postmenopausal breast cancer incidence.  |  Stevens, VL., et al. 2007. Cancer Epidemiol Biomarkers Prev. 16: 1140-7. PMID: 17548676
6. One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia.  |  Lee, KM., et al. 2007. Hum Genet. 122: 525-33. PMID: 17891500
7. A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function.  |  Cahoy, JD., et al. 2008. J Neurosci. 28: 264-78. PMID: 18171944
8. ALDH1L1 and ALDH1L2 Folate Regulatory Enzymes in Cancer.  |  Krupenko, SA. and Krupenko, NI. 2018. Adv Exp Med Biol. 1032: 127-143. PMID: 30362096
9. Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression.  |  Krupenko, SA. and Krupenko, NI. 2019. Chem Biol Interact. 302: 149-155. PMID: 30794800
10. Structure of putative tumor suppressor ALDH1L1.  |  Tsybovsky, Y., et al. 2022. Commun Biol. 5: 3. PMID: 35013550
11. Aldh1l1-Cre/ER T2 is expressed in unintended cell types of the salivary gland, pancreas, and spleen.  |  Nemeth, D., et al. 2023. MicroPubl Biol. 2023: PMID: 37273576
12. Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice.  |  Champion, KM., et al. 1994. Proc Natl Acad Sci U S A. 91: 11338-42. PMID: 7972060

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aldehyde dehydrogenase 1-L1/ALDH1L1 Antibody (YY8) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-Aldehyde dehydrogenase 1-L1/ALDH1L1 Antibody (YY8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aldehyde dehydrogenase 1-L1/ALDH1L1 Antibody (YY8) Specifications

Alternate Product Name: ALDH1L1

Product Clone Name: YY8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 803-903

Epitope Target: ALDH1L1

Epitope Species: human

Product Reactivity/Detection: ALDH1L1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgG₃ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for Aldehyde dehydrogenase 1-L1/ALDH1L1 Antibody (YY8): N/A