NANS Background Information Sialic acids are a family of 9-carbon 2-keto-3-deoxy sugars that are found on the ends of glycoproteins and glycolipids and play important roles in recognition events within the cell. NANS (N-acetylneuraminic acid synthase), also known as SAS, is a 359 amino acid protein that contains one AFP (antifreeze proteins)-like domain and functions in the biosynthesis of sialic acids. Expressed ubiquitously, NANS enzymatically catalyzes the H2O-dependent formation of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), both of which are sialic acids. NANS uses N-acetylmannosamine 6-phosphate as a substrate for Neu5Ac synthesis and mannose 6-phosphate as a substrate for KDN synthesis. Human NANS shares 36% identity with the E. coli protein neuB, suggesting a conserved function between species.
NANS (3D7)
点击使图像放大
NANS (3D7): sc-100484. Western blot analysis of NANS expression in HeLa whole cell lysate.
NANS (3D7): sc-100484. Western blot analysis of NANS expression in 293T whole cell lysate.
NANS (3D7): sc-100484. Western blot analysis of NANS expression in non-transfected 293T: sc-117752 (A), human NANS transfected 293T: sc-170911 (B) and HeLa (C) whole cell lysates.
