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X11 AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of X11 antibodies. Select X11 antibodies from several monoclonal and/or polyclonal X11 antibodies listed below. View detailed X11 antibody specifications by linking to the specific product blocks. Select appropriate X11 antibodies for your research by isotype, epitope, applications and species reactivity. X11 gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of X11 Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.Also see additional X11 Antibodies including, X11 alpha, X11beta, X11gamma
X11 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
The β-Amyloid precursor protein (β-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The β-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the β-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular β-APP and slowing β-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of β-APP. Multiple splice varitents of X11 have been identified, including X11α (also designated Mint 1), X11β (Mint 2) and X11γ (Mint 3). |
