Ubp Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of Ubp antibodies. Select Ubp antibodies from several monoclonal and/or polyclonal Ubp antibodies listed below. View detailed Ubp antibody specifications by linking to the specific product blocks. Select appropriate Ubp antibodies for your research by isotype, epitope, applications and species reactivity. Ubp gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available.

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Ubiquitin-processing protease-M (Ubp-M) belongs to a family of enzymes that regulate the degradation of ubiquitinated proteins by deubiquitination. Ubiquitin-mediated proteolysis requires the transfer of ubiquitin chains to lysine groups on selected cellular proteins, which then potentiates the pro-teolytic degradation of these conjugated substrates by the 26S proteasome. Ubps, which are also designated deubiquitinating enzymes (DUBs), regulate growth activity and differentiation. Ubp-M is localized to the cytosol and is phosphorylated during the G₂/M phase transition through the completion of mitosis. This phosphorylation state coincides with an accumulation of free ubiquitin chains within the cell and an increased hydrolysis of ubiquitin conjugated proteins. Targets of Ubp-M include the histone proteins H2A and H2B, which are monoubiquitinated during interphase and anaphase and are deubuiquitinated during mitoisis. This deubiquitination of the histone proteins correlates to the condensation of the mitotic chromatin, indicating that Ubp-M influences histone function and, thereby, facilitates the organization of mitotic chromatin and directs the progression of cell growth.