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U2AF65 AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of U2AF65 antibodies. Select U2AF65 antibodies from several monoclonal and/or polyclonal U2AF65 antibodies listed below. View detailed U2AF65 antibody specifications by linking to the specific product blocks. Select appropriate U2AF65 antibodies for your research by isotype, epitope, applications and species reactivity. U2AF65 gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of U2AF65 Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
U2AF65 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
SF3b is an U2 snRNP-associated protein complex essential for spliceosome assembly. SF3b contains the spliceosomal proteins SAPs 49, 130, 145 and 155. SAPs 130, 145 and 155 associate with one another to form a complex that is present in HeLa nuclear extracts. SAPs 49 and 145 are known to interact directly with each other. Unexpectedly, the SAP 49-SAP 145 protein-protein interaction requires the amino-terminus of SAP 49, which contains two RNA-recognition motifs. SAP 49 and SAP 145 interact directly with both U2 snRNP and the pre-mRNA, which suggests that this protein complex plays a role in tethering U2 snRNP to the branch site. U2AF recruits SAP 49 to the branch point sequence during the initial steps of spliceosome assembly. U2AF exists as a heterodimer consisting of U2AF65 and U2AF35 and is required for splicing in vivo. |
