TTYH Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of TTYH antibodies. Select TTYH antibodies from several monoclonal and/or polyclonal TTYH antibodies listed below. View detailed TTYH antibody specifications by linking to the specific product blocks. Select appropriate TTYH antibodies for your research by isotype, epitope, applications and species reactivity. TTYH gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available.

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Also see additional TTYH Antibodies including, TTYH1, TTYH2, TTYH3

The tweety family of proteins are membrane bound receptors that function as chloride anion channels and may be involved in transport of iron or other divalent cations. TTYH1 (tweety homolog 1, Drosophila melanogaster, is a 450 amino acid multi-pass membrane protein that belongs to the tweety family and is expressed in brain, eye, ovary and testis, with lower expression in muscle, placenta, liver and lung. Composed of five predicted transmembrane segments and a C-terminus that is enriched in negatively charged residues capable of Ca²⁺ binding, TTYH1 may play a role during mitosis in early embryogenesis, possibly by maintaining Ca²⁺ homeostasis in the endoplasmic reticulum. TTYH1 exists as five alternatively spliced isoforms, where isoform 3 is considered a possible Ca²⁺-independent and swelling-activated chloride channel, which may be involved in regulation of cell volume. TTYH1 is regulated by NEDD4-L and is encoded by a gene located on human chromosome 19q13.42.