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Topo Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of Topo antibodies. Select Topo antibodies from several monoclonal and/or polyclonal Topo antibodies listed below. View detailed Topo antibody specifications by linking to the specific product blocks. Select appropriate Topo antibodies for your research by isotype, epitope, applications and species reactivity. Topo gene silencer products in siRNA, shRNA Plasmid, shRNA Lentiviral Particle and CRISPR/Cas9 Knockout Plasmid formats are also available as well as CRISPR/dCas9 Activation Plasmids for gene activation.

Introducing HOVERcruz™,

a unique system for rapid identification of Topo Antibodies. Hover over product names in the table to see representative data for each product.

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Our live chat system is available to answer your product and ordering questions.

See chemical Topo Inhibitors for functional analysis of cellular responses to Topo.

Also see additional Topo Antibodies including, Topo I, Topo II, Topo III alpha, Topo III beta-1, Topo III beta-2, Topo III beta-3, Topo II alpha... See More, Topo II beta

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
Topo I (H-5)sc-271285mouse IgG1685-765 (h)WB, IP, IF, ELISAhuman, e, c, b, p1
Topo I (C-15)sc-5342goat IgGC-terminal (h)WB, IP, IF, FCM, ELISAm, r, h, e, b, p, c, a12
Topo I (C-21)sc-32736mouse IgMFL (h)WB, IP, IF, IHC(P)human2
Topo I (H-300)sc-10783rabbit IgG685-765 (h)WB, IP, IF, IHC(P), ELISAm, r, h, c, b, p, a, e13
Topo IIα (B-6)sc-365918mouse IgG2b1483-1517 (h)WB, IP, IF, ELISAhuman
Topo IIα (C-15)sc-5346goat IgGC-terminal (h)WB, IP, IF, ELISAm, r, h, c, p, e7
Topo IIα (E-10)sc-365799mouse IgM1511-1530 (h)WB, IP, IF, ELISAm, r, h, p
Topo IIα (E-11)sc-365917mouse IgG11483-1517 (h)WB, IP, IF, ELISAhuman
Topo IIα (G-9)sc-166232mouse IgG11301-1531 (h)WB, IP, IF, ELISAhuman
Topo IIα (G-6)sc-166934mouse IgG2b1301-1531 (h)WB, IP, IF, IHC(P), ELISAhuman
Topo IIα (F-12)sc-365916mouse IgG11511-1530 (h)WB, IP, IF, ELISAm, r, h, p
Topo IIα (H-231)sc-13058rabbit IgG1301-1531 (h)WB, IP, IF, ELISAh > m, r10
Topo IIα (K-19)sc-5347goat IgGC-terminal (h)WB, IP, IF, ELISAhuman4
Topo IIα (A-8)sc-165986mouse IgG11301-1531 (h)WB, IP, IF, ELISAhuman
Topo IIα (S-18)sc-5351goat IgGinternal (m)WB, IP, IF, ELISAm, r
Topo IIα (S-20)sc-5348goat IgGinternal (h)WB, IP, IF, IHC(P), ELISAh, p, e2
Topo IIα (3F6)sc-56803mouse IgG1N/AWB, IP, IF, IHC(P), FCMhuman3
Topo IIβ (A-12)sc-365071mouse IgG2a1579-1611 (h)WB, IP, IF, ELISAm, r, h
Topo IIβ (C-12)sc-48429mouse IgG11341-1626 (h)WB, IP, IF, ELISAh, r
Topo IIβ (B-6)sc-365952mouse IgG11579-1611 (h)WB, IP, IF, ELISAm, r, h
Topo IIβ (C-19)sc-5352goat IgGC-terminal (h)WB, IP, IF, ELISAm, r, h, e, c2
Topo IIβ (D-1)sc-365421mouse IgG31579-1611 (h)WB, IP, IF, ELISAm, r, h
Topo IIβ (F-19)sc-5353goat IgGC-terminal (h)WB, IP, IF, ELISAm, r, h, e, c, b
Topo IIβ (H-286)sc-13059rabbit IgG1341-1626 (h)WB, IP, IF, IHC(P), ELISAm, r, h, c, b, e12
Topo IIβ (H-8)sc-25330mouse IgG11341-1626 (h)WB, IP, IF, IHC(P), ELISAh, r3
Topo IIIα (N-20)sc-11257goat IgGN-terminal (h)WB, IP, IF, IHC(P), ELISAhuman1
Topo IIIα (H-300)sc-13060rabbit IgG702-1001 (h)WB, IP, IF, ELISAm, r, h
Topo IIIα (E-17)sc-11258goat IgGN-terminal (h)WB, IF, ELISAm, r, h, e, c, b, a
Topo IIIβ-1 (B-10)sc-137238mouse IgG2b563-862 (h)WB, IP, IF, ELISAhuman
Topo IIIβ-1 (E-13)sc-11266goat IgGinternal (h)WB, IP, IF, ELISAm, r, h, e, c, b, p
Topo IIIβ-1 (H-300)sc-13061rabbit IgG563-862 (h)WB, IP, IF, IHC(P), ELISAm, r, h, e, c, b, p, a
Topo IIIβ-1,2,3 (D-16)sc-11264goat IgGinternal (h)WB, IP, IF, ELISAm, r, h, e, c, b, p, a
Topo IIIβ-2 (H-20)sc-11268goat IgGinternal (h)WB, IF, ELISAhuman
Topo IIIβ-1,2,3 (L-17)sc-11265goat IgGinternal (h)WB, IF, ELISAm, r, h, e, c, b, p, a

Phospho-Specific Topo Antibodies

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
p-Topo IIα (Thr 1343)sc-16742goat IgGThr 1343 (h)WB, IP, IF, IHC(P), ELISAhuman

Non-Mammalian Topo Antibodies

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
Topo I (aP-17)sc-12825goat IgGN-terminal (At)WB, IF, ELISAArabidopsis
Topo II (T22C5)sc-65743mouse IgG1FL (d)WB, IPDrosophila
Topo II (T21D4)sc-65742mouse IgG2bFL (d)WBDrosophila

Topo CRISPR Knockout and HDR Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSCITATIONSRATING
Topo IIβ CRISPR/Cas9 KO Plasmid (h)sc-400773humanGene KnockoutNEWNot Yet Rated
Topo IIβ HDR Plasmid (h)sc-400773-HDRhumanHomology Directed RepairNEWNot Yet Rated
Topo IIα CRISPR/Cas9 KO Plasmid (h)sc-400869humanGene KnockoutNEWNot Yet Rated
Topo IIα HDR Plasmid (h)sc-400869-HDRhumanHomology Directed RepairNEWNot Yet Rated
Topo I CRISPR/Cas9 KO Plasmid (h)sc-400965humanGene KnockoutNEWNot Yet Rated
Topo I HDR Plasmid (h)sc-400965-HDRhumanHomology Directed RepairNEWNot Yet Rated
Topo IIIα CRISPR/Cas9 KO Plasmid (h)sc-404439humanGene KnockoutNEWNot Yet Rated
Topo IIIα HDR Plasmid (h)sc-404439-HDRhumanHomology Directed RepairNEWNot Yet Rated
Topo IIIβ CRISPR/Cas9 KO Plasmid (h)sc-406840humanGene KnockoutNEWNot Yet Rated
Topo IIIβ HDR Plasmid (h)sc-406840-HDRhumanHomology Directed RepairNEWNot Yet Rated
Topo I CRISPR/Cas9 KO Plasmid (m)sc-423468mouseGene KnockoutNEWNot Yet Rated
Topo I HDR Plasmid (m)sc-423468-HDRmouseHomology Directed RepairNEWNot Yet Rated
Topo IIα CRISPR/Cas9 KO Plasmid (m)sc-423469mouseGene KnockoutNEWNot Yet Rated
Topo IIα HDR Plasmid (m)sc-423469-HDRmouseHomology Directed RepairNEWNot Yet Rated
Topo IIβ CRISPR/Cas9 KO Plasmid (m)sc-423470mouseGene KnockoutNEWNot Yet Rated
Topo IIβ HDR Plasmid (m)sc-423470-HDRmouseHomology Directed RepairNEWNot Yet Rated
Topo IIIα CRISPR/Cas9 KO Plasmid (m)sc-423471mouseGene KnockoutNEWNot Yet Rated
Topo IIIα HDR Plasmid (m)sc-423471-HDRmouseHomology Directed RepairNEWNot Yet Rated
Topo IIIβ CRISPR/Cas9 KO Plasmid (m)sc-423472mouseGene KnockoutNEWNot Yet Rated
Topo IIIβ HDR Plasmid (m)sc-423472-HDRmouseHomology Directed RepairNEWNot Yet Rated

Topo CRISPR Activation Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSCITATIONSRATING
Topo IIβ CRISPR Activation Plasmid (h)sc-400773-ACThumanGene ActivationNEWNot Yet Rated
Topo IIα CRISPR Activation Plasmid (h)sc-400869-ACThumanGene ActivationNEWNot Yet Rated
Topo I CRISPR Activation Plasmid (h)sc-400965-ACThumanGene ActivationNEWNot Yet Rated
Topo IIIα CRISPR Activation Plasmid (h)sc-404439-ACThumanGene ActivationNEWNot Yet Rated
Topo IIIβ CRISPR Activation Plasmid (h)sc-406840-ACThumanGene ActivationNEWNot Yet Rated
Topo I CRISPR Activation Plasmid (m)sc-423468-ACTmouseGene ActivationNEWNot Yet Rated
Topo IIå CRISPR Activation Plasmid (m)sc-423469-ACTmouseGene ActivationNEWNot Yet Rated
Topo II∫ CRISPR Activation Plasmid (m)sc-423470-ACTmouseGene ActivationNEWNot Yet Rated
Topo IIIå CRISPR Activation Plasmid (m)sc-423471-ACTmouseGene ActivationNEWNot Yet Rated
Topo III∫ CRISPR Activation Plasmid (m)sc-423472-ACTmouseGene ActivationNEWNot Yet Rated

Topo siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSCITATIONSRATING
Topo I siRNA (m)sc-36693mouseGene SilencingNot Yet Rated
Topo I shRNA Plasmid (m)sc-36693-SHmouseGene SilencingNot Yet Rated
Topo I shRNA (m) Lentiviral Particlessc-36693-VmouseGene SilencingNot Yet Rated
Topo I siRNA (h)sc-36694humanGene Silencing2
Topo I shRNA Plasmid (h)sc-36694-SHhumanGene Silencing
Topo I shRNA (h) Lentiviral Particlessc-36694-VhumanGene Silencing
Topo IIα siRNA (h)sc-36695humanGene Silencing1
Topo IIα shRNA Plasmid (h)sc-36695-SHhumanGene Silencing
Topo IIα shRNA (h) Lentiviral Particlessc-36695-VhumanGene Silencing
Topo IIα siRNA (m)sc-36696mouseGene Silencing
Topo IIα shRNA Plasmid (m)sc-36696-SHmouseGene Silencing
Topo IIα shRNA (m) Lentiviral Particlessc-36696-VmouseGene Silencing
Topo IIβ siRNA (h)sc-36697humanGene Silencing
Topo IIβ shRNA Plasmid (h)sc-36697-SHhumanGene Silencing
Topo IIβ shRNA (h) Lentiviral Particlessc-36697-VhumanGene Silencing
Topo IIβ siRNA (m)sc-36698mouseGene Silencing
Topo IIβ shRNA Plasmid (m)sc-36698-SHmouseGene Silencing
Topo IIβ shRNA (m) Lentiviral Particlessc-36698-VmouseGene Silencing
Topo IIIα siRNA (h)sc-36699humanGene SilencingNot Yet Rated
Topo IIIα shRNA Plasmid (h)sc-36699-SHhumanGene SilencingNot Yet Rated
Topo IIIα shRNA (h) Lentiviral Particlessc-36699-VhumanGene SilencingNot Yet Rated
Topo IIIα siRNA (m)sc-36700mouseGene SilencingNot Yet Rated
Topo IIIα shRNA Plasmid (m)sc-36700-SHmouseGene SilencingNot Yet Rated
Topo IIIα shRNA (m) Lentiviral Particlessc-36700-VmouseGene SilencingNot Yet Rated
Topo IIIβ siRNA (h)sc-36701humanGene SilencingNot Yet Rated
Topo IIIβ shRNA Plasmid (h)sc-36701-SHhumanGene SilencingNot Yet Rated
Topo IIIβ shRNA (h) Lentiviral Particlessc-36701-VhumanGene SilencingNot Yet Rated
Topo IIIβ siRNA (m)sc-36702mouseGene SilencingNot Yet Rated
Topo IIIβ shRNA Plasmid (m) sc-36702-SHmouseGene SilencingNot Yet Rated
Topo IIIβ shRNA (m) Lentiviral Particles sc-36702-VmouseGene SilencingNot Yet Rated
Topo IIIβ-2 siRNA (h)sc-37809humanGene SilencingNot Yet Rated
Topo IIIβ-2 shRNA Plasmid (h)sc-37809-SHhumanGene SilencingNot Yet Rated
Topo IIIβ-2 shRNA (h) Lentiviral Particlessc-37809-VhumanGene SilencingNot Yet Rated
Topo IIβ siRNA (h2)sc-44161humanGene SilencingNot Yet Rated
Topo IIβ shRNA Plasmid (h2)sc-44161-SHhumanGene SilencingNot Yet Rated
Topo IIβ shRNA (h2) Lentiviral Particlessc-44161-VhumanGene SilencingNot Yet Rated

DNA topoisomerase I and II (Topo I and Topo II) are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Eukaryotic topoisomerases are capable of relaxing both positive and negative supercoils, whereas prokaryotic topoisomerases relax only negative supercoils. DNA topoisomerases play a role in DNA replication, recombination, and transcription and have been identified as targets of numerous anticancer drugs. Topo I, a ubiquitously expressed, soluble enzyme, acts by introducing a transient break in one strand of DNA, while Topo II acts by making a transient double-strand break. Topo II is encoded by two different genes to generate two distinct isoforms that are designated Topo IIα and Topo IIβ. Topo IIβ and Topo IIα, are largely homologous at their N-terminal three quarters, however, the C-terminal segments are considerably divergent, suggesting that these regions may mediate different cellular functions and account for the observed differential tissue expression patterns of the two isoforms.