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Topo Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of Topo antibodies. Select Topo antibodies from several monoclonal and/or polyclonal Topo antibodies listed below. View detailed Topo antibody specifications by linking to the specific product blocks. Select appropriate Topo antibodies for your research by isotype, epitope, applications and species reactivity. Topo gene silencer products in siRNA, shRNA Plasmid, shRNA Lentiviral Particle, CRISPR/Cas9 Knockout and CRISPR Double Nickase Plasmid formats are also available as well as CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems for gene activation.

Introducing HOVERcruz™,

a unique system for rapid identification of Topo Antibodies. Hover over the icon next to the product names in the table to see representative data for that product.

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Our live chat system is available to answer your product and ordering questions.

See chemical Topo Inhibitors for functional analysis of cellular responses to Topo.

Also see additional Topo Antibodies including, Topo I, Topo II, Topo III alpha, Topo III beta-1, Topo III beta-2, Topo III beta-3, Topo II alpha... See More, Topo II beta

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
Topo I (H-5)
sc-271285mouse IgG1685-765 (h)WB, IP, IF, ELISAhuman, e, c, b, p1
Topo I (C-15)
sc-5342goat IgGC-terminal (h)WB, IP, IF, FCM, ELISAm, r, h, e, b, p, c, a12
Topo I (C-21)
sc-32736mouse IgMFL (h)WB, IP, IF, IHC(P)human2
Topo I (H-300)
sc-10783rabbit IgG685-765 (h)WB, IP, IF, IHC(P), ELISAm, r, h, c, b, p, a, e13
Topo IIα (B-6)
sc-365918mouse IgG2b1483-1517 (h)WB, IP, IF, ELISAhuman
Topo IIα (C-15)
sc-5346goat IgGC-terminal (h)WB, IP, IF, ELISAm, r, h, c, p, e7
Topo IIα (E-10)
sc-365799mouse IgM1511-1530 (h)WB, IP, IF, ELISAm, r, h, p
Topo IIα (E-11)
sc-365917mouse IgG11483-1517 (h)WB, IP, IF, ELISAhuman
Topo IIα (G-9)
sc-166232mouse IgG11301-1531 (h)WB, IP, IF, ELISAhuman
Topo IIα (G-6)
sc-166934mouse IgG2b1301-1531 (h)WB, IP, IF, IHC(P), ELISAhuman
Topo IIα (F-12)
sc-365916mouse IgG11511-1530 (h)WB, IP, IF, ELISAm, r, h, p
Topo IIα (H-231)
sc-13058rabbit IgG1301-1531 (h)WB, IP, IF, ELISAh > m, r10
Topo IIα (K-19)
sc-5347goat IgGC-terminal (h)WB, IP, IF, ELISAhuman4
Topo IIα (A-8)
sc-165986mouse IgG11301-1531 (h)WB, IP, IF, ELISAhuman
Topo IIα (S-18)
sc-5351goat IgGinternal (m)WB, IP, IF, ELISAm, r
Topo IIα (S-20)
sc-5348goat IgGinternal (h)WB, IP, IF, IHC(P), ELISAh, p, e2
Topo IIα (3F6)
sc-56803mouse IgG1N/AWB, IP, IF, IHC(P), FCMhuman3
Topo IIβ (A-12)
sc-365071mouse IgG2a1579-1611 (h)WB, IP, IF, ELISAm, r, h
Topo IIβ (C-12)
sc-48429mouse IgG11341-1626 (h)WB, IP, IF, ELISAh, r
Topo IIβ (B-6)
sc-365952mouse IgG11579-1611 (h)WB, IP, IF, ELISAm, r, h
Topo IIβ (C-19)
sc-5352goat IgGC-terminal (h)WB, IP, IF, ELISAm, r, h, e, c2
Topo IIβ (D-1)
sc-365421mouse IgG31579-1611 (h)WB, IP, IF, ELISAm, r, h
Topo IIβ (F-19)
sc-5353goat IgGC-terminal (h)WB, IP, IF, ELISAm, r, h, e, c, b
Topo IIβ (H-286)
sc-13059rabbit IgG1341-1626 (h)WB, IP, IF, IHC(P), ELISAm, r, h, c, b, e12
Topo IIβ (H-8)
sc-25330mouse IgG11341-1626 (h)WB, IP, IF, IHC(P), ELISAh, r3
Topo IIIα (N-20)
sc-11257goat IgGN-terminal (h)WB, IP, IF, IHC(P), ELISAhuman1
Topo IIIα (H-300)
sc-13060rabbit IgG702-1001 (h)WB, IP, IF, ELISAm, r, h
Topo IIIα (E-17)
sc-11258goat IgGN-terminal (h)WB, IF, ELISAm, r, h, e, c, b, a
Topo IIIβ-1 (B-10)
sc-137238mouse IgG2b563-862 (h)WB, IP, IF, ELISAhuman
Topo IIIβ-1 (E-13)
sc-11266goat IgGinternal (h)WB, IP, IF, ELISAm, r, h, e, c, b, p
Topo IIIβ-1 (H-300)
sc-13061rabbit IgG563-862 (h)WB, IP, IF, IHC(P), ELISAm, r, h, e, c, b, p, a
Topo IIIβ-1,2,3 (D-16)
sc-11264goat IgGinternal (h)WB, IP, IF, ELISAm, r, h, e, c, b, p, a
Topo IIIβ-2 (H-20)
sc-11268goat IgGinternal (h)WB, IF, ELISAhuman
Topo IIIβ-1,2,3 (L-17)
sc-11265goat IgGinternal (h)WB, IF, ELISAm, r, h, e, c, b, p, a

Phospho-Specific Topo Antibodies

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
p-Topo IIα (Thr 1343)
sc-16742goat IgGThr 1343 (h)WB, IP, IF, IHC(P), ELISAhuman

Non-Mammalian Topo Antibodies

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
Topo I (aP-17)
sc-12825goat IgGN-terminal (At)WB, IF, ELISAArabidopsis
Topo II (T22C5)
sc-65743mouse IgG1FL (d)WB, IPDrosophila
Topo II (T21D4)
sc-65742mouse IgG2bFL (d)WBDrosophila

Topo CRISPR Knockout, HDR and Nickase Knockout Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
Topo IIβ CRISPR/Cas9 KO Plasmid (h)
sc-400773humanGene KnockoutGFPNEW
Topo IIβ HDR Plasmid (h)
sc-400773-HDRhumanHomology Directed RepairPuromycinNEW
Topo IIβ Double Nickase Plasmid (h)
sc-400773-NIChumanGene KnockoutPuromycinNEW
Topo IIβ Double Nickase Plasmid (h2)
sc-400773-NIC-2humanGene KnockoutPuromycinNEW
Topo IIα CRISPR/Cas9 KO Plasmid (h)
sc-400869humanGene KnockoutGFPNEW
Topo IIα HDR Plasmid (h)
sc-400869-HDRhumanHomology Directed RepairPuromycinNEW
Topo IIα Double Nickase Plasmid (h)
sc-400869-NIChumanGene KnockoutPuromycinNEW
Topo IIα Double Nickase Plasmid (h2)
sc-400869-NIC-2humanGene KnockoutPuromycinNEW
Topo I CRISPR/Cas9 KO Plasmid (h)
sc-400965humanGene KnockoutGFPNEW
Topo I HDR Plasmid (h)
sc-400965-HDRhumanHomology Directed RepairPuromycinNEW
Topo I Double Nickase Plasmid (h)
sc-400965-NIChumanGene KnockoutPuromycinNEW
Topo I Double Nickase Plasmid (h2)
sc-400965-NIC-2humanGene KnockoutPuromycinNEW
Topo IIIα CRISPR/Cas9 KO Plasmid (h)
sc-404439humanGene KnockoutGFPNEW
Topo IIIα HDR Plasmid (h)
sc-404439-HDRhumanHomology Directed RepairPuromycinNEW
Topo IIIα Double Nickase Plasmid (h)
sc-404439-NIChumanGene KnockoutPuromycinNEW
Topo IIIα Double Nickase Plasmid (h2)
sc-404439-NIC-2humanGene KnockoutPuromycinNEW
Topo IIIβ CRISPR/Cas9 KO Plasmid (h)
sc-406840humanGene KnockoutGFPNEW
Topo IIIβ HDR Plasmid (h)
sc-406840-HDRhumanHomology Directed RepairPuromycinNEW
Topo IIIβ Double Nickase Plasmid (h)
sc-406840-NIChumanGene KnockoutPuromycinNEW
Topo IIIβ Double Nickase Plasmid (h2)
sc-406840-NIC-2humanGene KnockoutPuromycinNEW
Topo I CRISPR/Cas9 KO Plasmid (m)
sc-423468mouseGene KnockoutGFPNEW
Topo I HDR Plasmid (m)
sc-423468-HDRmouseHomology Directed RepairPuromycinNEW
Topo I Double Nickase Plasmid (m)
sc-423468-NICmouseGene KnockoutPuromycinNEW
Topo I Double Nickase Plasmid (m2)
sc-423468-NIC-2mouseGene KnockoutPuromycinNEW
Topo IIα CRISPR/Cas9 KO Plasmid (m)
sc-423469mouseGene KnockoutGFPNEW
Topo IIα HDR Plasmid (m)
sc-423469-HDRmouseHomology Directed RepairPuromycinNEW
Topo IIα Double Nickase Plasmid (m)
sc-423469-NICmouseGene KnockoutPuromycinNEW
Topo IIα Double Nickase Plasmid (m2)
sc-423469-NIC-2mouseGene KnockoutPuromycinNEW
Topo IIβ CRISPR/Cas9 KO Plasmid (m)
sc-423470mouseGene KnockoutGFPNEW
Topo IIβ HDR Plasmid (m)
sc-423470-HDRmouseHomology Directed RepairPuromycinNEW
Topo IIβ Double Nickase Plasmid (m)
sc-423470-NICmouseGene KnockoutPuromycinNEW
Topo IIβ Double Nickase Plasmid (m2)
sc-423470-NIC-2mouseGene KnockoutPuromycinNEW
Topo IIIα CRISPR/Cas9 KO Plasmid (m)
sc-423471mouseGene KnockoutGFPNEW
Topo IIIα HDR Plasmid (m)
sc-423471-HDRmouseHomology Directed RepairPuromycinNEW
Topo IIIα Double Nickase Plasmid (m)
sc-423471-NICmouseGene KnockoutPuromycinNEW
Topo IIIα Double Nickase Plasmid (m2)
sc-423471-NIC-2mouseGene KnockoutPuromycinNEW
Topo IIIβ CRISPR/Cas9 KO Plasmid (m)
sc-423472mouseGene KnockoutGFPNEW
Topo IIIβ HDR Plasmid (m)
sc-423472-HDRmouseHomology Directed RepairPuromycinNEW
Topo IIIβ Double Nickase Plasmid (m)
sc-423472-NICmouseGene KnockoutPuromycinNEW
Topo IIIβ Double Nickase Plasmid (m2)
sc-423472-NIC-2mouseGene KnockoutPuromycinNEW

Topo CRISPR Activation Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
Topo IIβ CRISPR Activation Plasmid (h)
sc-400773-ACThumanGene ActivationZeo, Blast, HygroNEW
Topo IIβ CRISPR Activation Plasmid (h2)
sc-400773-ACT-2humanGene ActivationZeo, Blast, HygroNEW
Topo IIβ Lenti Activation System (h)
sc-400773-LAChumanGene ActivationZeo, Blast, HygroNEW
Topo IIβ Lenti Activation System (h2)
sc-400773-LAC-2humanGene ActivationZeo, Blast, HygroNEW
Topo IIα CRISPR Activation Plasmid (h)
sc-400869-ACThumanGene ActivationZeo, Blast, HygroNEW
Topo IIα CRISPR Activation Plasmid (h2)
sc-400869-ACT-2humanGene ActivationZeo, Blast, HygroNEW
Topo IIα Lenti Activation System (h)
sc-400869-LAChumanGene ActivationZeo, Blast, HygroNEW
Topo IIα Lenti Activation System (h2)
sc-400869-LAC-2humanGene ActivationZeo, Blast, HygroNEW
Topo I CRISPR Activation Plasmid (h)
sc-400965-ACThumanGene ActivationZeo, Blast, HygroNEW
Topo I CRISPR Activation Plasmid (h2)
sc-400965-ACT-2humanGene ActivationZeo, Blast, HygroNEW
Topo I Lenti Activation System (h)
sc-400965-LAChumanGene ActivationZeo, Blast, HygroNEW
Topo I Lenti Activation System (h2)
sc-400965-LAC-2humanGene ActivationZeo, Blast, HygroNEW
Topo IIIα CRISPR Activation Plasmid (h)
sc-404439-ACThumanGene ActivationZeo, Blast, HygroNEW
Topo IIIα CRISPR Activation Plasmid (h2)
sc-404439-ACT-2humanGene ActivationZeo, Blast, HygroNEW
Topo IIIα Lenti Activation System (h)
sc-404439-LAChumanGene ActivationZeo, Blast, HygroNEW
Topo IIIα Lenti Activation System (h2)
sc-404439-LAC-2humanGene ActivationZeo, Blast, HygroNEW
Topo IIIβ CRISPR Activation Plasmid (h)
sc-406840-ACThumanGene ActivationZeo, Blast, HygroNEW
Topo IIIβ CRISPR Activation Plasmid (h2)
sc-406840-ACT-2humanGene ActivationZeo, Blast, HygroNEW
Topo IIIβ Lenti Activation System (h)
sc-406840-LAChumanGene ActivationZeo, Blast, HygroNEW
Topo IIIβ Lenti Activation System (h2)
sc-406840-LAC-2humanGene ActivationZeo, Blast, HygroNEW
Topo I CRISPR Activation Plasmid (m)
sc-423468-ACTmouseGene ActivationZeo, Blast, HygroNEW
Topo I CRISPR Activation Plasmid (m2)
sc-423468-ACT-2mouseGene ActivationZeo, Blast, HygroNEW
Topo I Lenti Activation System (m)
sc-423468-LACmouseGene ActivationZeo, Blast, HygroNEW
Topo I Lenti Activation System (m2)
sc-423468-LAC-2mouseGene ActivationZeo, Blast, HygroNEW
Topo IIα CRISPR Activation Plasmid (m)
sc-423469-ACTmouseGene ActivationZeo, Blast, HygroNEW
Topo IIα CRISPR Activation Plasmid (m2)
sc-423469-ACT-2mouseGene ActivationZeo, Blast, HygroNEW
Topo IIα Lenti Activation System (m)
sc-423469-LACmouseGene ActivationZeo, Blast, HygroNEW
Topo IIα Lenti Activation System (m2)
sc-423469-LAC-2mouseGene ActivationZeo, Blast, HygroNEW
Topo IIβ CRISPR Activation Plasmid (m)
sc-423470-ACTmouseGene ActivationZeo, Blast, HygroNEW
Topo IIβ CRISPR Activation Plasmid (m2)
sc-423470-ACT-2mouseGene ActivationZeo, Blast, HygroNEW
Topo IIβ Lenti Activation System (m)
sc-423470-LACmouseGene ActivationZeo, Blast, HygroNEW
Topo IIβ Lenti Activation System (m2)
sc-423470-LAC-2mouseGene ActivationZeo, Blast, HygroNEW
Topo IIIα CRISPR Activation Plasmid (m)
sc-423471-ACTmouseGene ActivationZeo, Blast, HygroNEW
Topo IIIα CRISPR Activation Plasmid (m2)
sc-423471-ACT-2mouseGene ActivationZeo, Blast, HygroNEW
Topo IIIα Lenti Activation System (m)
sc-423471-LACmouseGene ActivationZeo, Blast, HygroNEW
Topo IIIα Lenti Activation System (m2)
sc-423471-LAC-2mouseGene ActivationZeo, Blast, HygroNEW
Topo IIIβ CRISPR Activation Plasmid (m)
sc-423472-ACTmouseGene ActivationZeo, Blast, HygroNEW
Topo IIIβ CRISPR Activation Plasmid (m2)
sc-423472-ACT-2mouseGene ActivationZeo, Blast, HygroNEW
Topo IIIβ Lenti Activation System (m)
sc-423472-LACmouseGene ActivationZeo, Blast, HygroNEW
Topo IIIβ Lenti Activation System (m2)
sc-423472-LAC-2mouseGene ActivationZeo, Blast, HygroNEW

Topo siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
Topo I siRNA (m)
sc-36693mouseGene SilencingN/A
Topo I shRNA Plasmid (m)
sc-36693-SHmouseGene SilencingPuromycin
Topo I shRNA (m) Lentiviral Particles
sc-36693-VmouseGene SilencingPuromycin
Topo I siRNA (h)
sc-36694humanGene SilencingN/A2
Topo I shRNA Plasmid (h)
sc-36694-SHhumanGene SilencingPuromycin
Topo I shRNA (h) Lentiviral Particles
sc-36694-VhumanGene SilencingPuromycin
Topo IIα siRNA (h)
sc-36695humanGene SilencingN/A1
Topo IIα shRNA Plasmid (h)
sc-36695-SHhumanGene SilencingPuromycin
Topo IIα shRNA (h) Lentiviral Particles
sc-36695-VhumanGene SilencingPuromycin
Topo IIα siRNA (m)
sc-36696mouseGene SilencingN/A
Topo IIα shRNA Plasmid (m)
sc-36696-SHmouseGene SilencingPuromycin
Topo IIα shRNA (m) Lentiviral Particles
sc-36696-VmouseGene SilencingPuromycin
Topo IIβ siRNA (h)
sc-36697humanGene SilencingN/A
Topo IIβ shRNA Plasmid (h)
sc-36697-SHhumanGene SilencingPuromycin
Topo IIβ shRNA (h) Lentiviral Particles
sc-36697-VhumanGene SilencingPuromycin
Topo IIβ siRNA (m)
sc-36698mouseGene SilencingN/A
Topo IIβ shRNA Plasmid (m)
sc-36698-SHmouseGene SilencingPuromycin
Topo IIβ shRNA (m) Lentiviral Particles
sc-36698-VmouseGene SilencingPuromycin
Topo IIIα siRNA (h)
sc-36699humanGene SilencingN/A
Topo IIIα shRNA Plasmid (h)
sc-36699-SHhumanGene SilencingPuromycin
Topo IIIα shRNA (h) Lentiviral Particles
sc-36699-VhumanGene SilencingPuromycin
Topo IIIα siRNA (m)
sc-36700mouseGene SilencingN/A
Topo IIIα shRNA Plasmid (m)
sc-36700-SHmouseGene SilencingPuromycin
Topo IIIα shRNA (m) Lentiviral Particles
sc-36700-VmouseGene SilencingPuromycin
Topo IIIβ siRNA (h)
sc-36701humanGene SilencingN/A
Topo IIIβ shRNA Plasmid (h)
sc-36701-SHhumanGene SilencingPuromycin
Topo IIIβ shRNA (h) Lentiviral Particles
sc-36701-VhumanGene SilencingPuromycin
Topo IIIβ siRNA (m)
sc-36702mouseGene SilencingN/A
Topo IIIβ shRNA Plasmid (m)
sc-36702-SHmouseGene SilencingPuromycin
Topo IIIβ shRNA (m) Lentiviral Particles
sc-36702-VmouseGene SilencingPuromycin
Topo IIIβ-2 siRNA (h)
sc-37809humanGene SilencingN/A
Topo IIIβ-2 shRNA Plasmid (h)
sc-37809-SHhumanGene SilencingPuromycin
Topo IIIβ-2 shRNA (h) Lentiviral Particles
sc-37809-VhumanGene SilencingPuromycin
Topo IIβ siRNA (h2)
sc-44161humanGene SilencingN/A
Topo IIβ shRNA Plasmid (h2)
sc-44161-SHhumanGene SilencingPuromycin
Topo IIβ shRNA (h2) Lentiviral Particles
sc-44161-VhumanGene SilencingPuromycin

DNA topoisomerase I and II (Topo I and Topo II) are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Eukaryotic topoisomerases are capable of relaxing both positive and negative supercoils, whereas prokaryotic topoisomerases relax only negative supercoils. DNA topoisomerases play a role in DNA replication, recombination, and transcription and have been identified as targets of numerous anticancer drugs. Topo I, a ubiquitously expressed, soluble enzyme, acts by introducing a transient break in one strand of DNA, while Topo II acts by making a transient double-strand break. Topo II is encoded by two different genes to generate two distinct isoforms that are designated Topo IIα and Topo IIβ. Topo IIβ and Topo IIα, are largely homologous at their N-terminal three quarters, however, the C-terminal segments are considerably divergent, suggesting that these regions may mediate different cellular functions and account for the observed differential tissue expression patterns of the two isoforms.