TLK Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of TLK antibodies. Select TLK antibodies from several monoclonal and/or polyclonal TLK antibodies listed below. View detailed TLK antibody specifications by linking to the specific product blocks. Select appropriate TLK antibodies for your research by isotype, epitope, applications and species reactivity. TLK gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available.

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Also see additional TLK Antibodies including, TLK1, TLK2

PRODUCT NAME	CAT. #	ISOTYPE	EPITOPE	APPLICATIONS	SPECIES
TLK (F-20)	sc-11595	goat IgG	internal (h)	WB, IP, IF, ELISA	m, r, h, e, c, b, p, a
TLK (C-19)	sc-11596	goat IgG	internal (h)	WB, IF, ELISA	m, r, h, e, c, b, p, a
TLK1 (A-15)	sc-79281	goat IgG	Internal (h)	WB, IF, ELISA	m, r, h, e, c, b, p, a
TLK1 (C-20)	sc-79282	goat IgG	C-terminal (h)	WB, IF, ELISA	m, r, h, e, c, b, p, a
TLK1 (V-17)	sc-11594	goat IgG	internal (h)	WB, IP, IF, ELISA	m, r, h, c, b, p, a
TLK1 (P-17)	sc-79284	goat IgG	Internal (h)	WB, IF, ELISA	m, r, h, e, c, b, p, a
TLK1 (N-18)	sc-11591	goat IgG	N-terminus (h)	WB, IF, ELISA	m, r, h, e, c, b, p
TLK1 (D-15)	sc-11592	goat IgG	internal (h)	WB, IF, ELISA	m, r, h, e, c, b, p, a
TLK1 (S-32)	sc-100345	mouse IgG₃	FL (h)	WB, IP, IF, IHC(P), ELISA	m, h
TLK2 (C-15)	sc-11600	goat IgG	C-terminus (h)	WB, IF, ELISA	m, r, h, e, c, b, p
TLK2 (L-15)	sc-11599	goat IgG	C-terminus (h)	WB, IF, ELISA	m, r, h, e, c, b, p, a
TLK2 (Y-17)	sc-100346	mouse IgG₁	FL (h)	WB, IP, IF, IHC(P), ELISA	human

TLK siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

siRNAs	shRNA Plasmids	shRNA Lentiviral Particles
TLK1 siRNA (h): sc-45973	TLK1 shRNA Plasmid (h): sc-45973-SH	TLK1 shRNA (h) Lentiviral Particles: sc-45973-V
TLK1 siRNA (m): sc-45974	TLK1 shRNA Plasmid (m): sc-45974-SH	TLK1 shRNA (m) Lentiviral Particles: sc-45974-V
TLK2 siRNA (h): sc-106801	TLK2 shRNA Plasmid (h): sc-106801-SH	TLK2 shRNA (h) Lentiviral Particles: sc-106801-V
TLK2 siRNA (m): sc-154294	TLK2 shRNA Plasmid (m): sc-154294-SH	TLK2 shRNA (m) Lentiviral Particles: sc-154294-V

The Tousled-like kinases (TLK1 and TLK2, also designated PKU-β and PKU-α, respectively) are the human homologs of the Tousled gene from Arabidopsis thaliana, which encodes a Serine/Threonine kinase that is necessary for proper organ morphogenesis. Both TLKs contain a nuclear localization signal and a predicted coiled-coil region in the N-terminal domain. TLK is ubiquitously expressed, and is prevalent in mouse testis, especially in pachytene spermatocytes and round spermatids. It displays a propensity to dimerize through an interaction between its coiled-coil structure and is able to autophosphorylate, as well as phosphorylate exogenous substrates. TLK1 and TLK2 are regulated by the cell cycle, showing maximum activity during S phase. Subsequently, they are thought to regulate the development of multicellular organisms, including playing a key role in spermatogenesis, through a series of phosphorylations.