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SPRED AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of SPRED antibodies. Select SPRED antibodies from several monoclonal and/or polyclonal SPRED antibodies listed below. View detailed SPRED antibody specifications by linking to the specific product blocks. Select appropriate SPRED antibodies for your research by isotype, epitope, applications and species reactivity. SPRED gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of SPRED Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.Also see additional SPRED Antibodies including, SPRED1, SPRED2, SPRED3
SPRED siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
SPRED1 (sprouty-related, EVH1 domain containing 1), also known as NFLS, is a 444 amino acid protein that contains one KBD domain, one sprouty domain and one WH1 domain. Localized to the cell membrane and to cholesterol-rich membrane raft fractions, SPRED1 functions as a tyrosine kinase that regulates the activity of the ERK (also known as MAP kinase) cascade by inhibiting the growth-factor-mediated activation of ERK. SPRED1 can act independently as a homodimer or can function as a heterodimer with SPRED2 and, in addition to its ability to regulate ERK, is thought to negatively regulate the development of blood cells in bone marrow. Defects in the gene encoding SPRED1 are the cause of neurofibromatosis type 1-like syndrome (NFLS), an autosomal dominant disease that is characterized by multiple cafe-au-lait spots, axillary freckling and macrocephaly. SPRED3 is a 410 amino acid peripheral membrane protein belonging to the sprouty/SPRED family of proteins. SPRED3 functions as a tyrosine kinase that regulates the activity of the ERK (also known as MAP kinase) cascade by inhibiting the growth-factor-mediated activation of ERK. SPRED3 is subject to tyrosine phosphorylation and contains one KBD domain, one SPR (sprouty) domain and one WH1 domain. |
