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SPA-1 AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of SPA-1 antibodies. Select SPA-1 antibodies from several monoclonal and/or polyclonal SPA-1 antibodies listed below. View detailed SPA-1 antibody specifications by linking to the specific product blocks. Select appropriate SPA-1 antibodies for your research by isotype, epitope, applications and species reactivity. SPA-1 gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of SPA-1 Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
SPA-1 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
The SPA-1 (signal-induced proliferation-associated gene-1) protein is a principal RAP1 GTPase-activating protein in the hematopoietic progenitors and peripheral T cells. The SPA-1 gene is normally expressed in fetal and adult lymphohematopoietic tissues. Various types of mitogenic stimulation increase SPA-1 mRNA expression in normal lymphocytes. SPA-1 disrupts LFA-1-ICAM1-mediated adhesive interactions and subsequent T cell-receptor triggering and IL-2 production, possibly through inhibition of RAP1. Mice that are deficient for the SPA-1 gene develop age-dependent progression of T cell immunodeficiency followed by a spectrum of late onset myeloproliferative disorders, mimicking human chronic myeloid leukemia. SPA-1 also directly binds to AQP2 and plays a role in regulating AQP2 trafficking to the apical membrane. |
