- Research Products Primary Antibodies: Mammalian Phospho-Specific Antibodies Antibodies for IHC (Paraffin) Staining Flow Cytometry Veterinary Research Antibodies Primary Antibodies: Non-Mammalian siRNA and shRNA (plasmid and lentivirus) Products Protein A, G PLUS and L-Agarose Tissue Extracts and Cell Lysates Biologically Active and Purified Proteins Transfected Cell Lysates Secondary Antibodies, Control Antibodies and Normal Sera Specialty Reagents and Kits
- Chemicals
- Lab Supplies
- Animal Health
- What's New
- Information
- Support
Welcome to Santa Cruz Biotechnology!
 | |||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||
SNED AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of SNED antibodies. Select SNED antibodies from several monoclonal and/or polyclonal SNED antibodies listed below. View detailed SNED antibody specifications by linking to the specific product blocks. Select appropriate SNED antibodies for your research by isotype, epitope, applications and species reactivity. SNED gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of SNED Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.Also see additional SNED Antibodies including, SNED1
SNED siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
SNED1 (Sushi, nidogen and EGF-like domain-containing protein 1), also known as IRE-BP1 (Insulin-responsive element DNA-binding protein 1), is a 1,413 amino acid secreted protein that contains fifteen EGF-like domains, three fibronectin type-III domains, two follistatin-like domains, one NIDO domain and one Sushi domain. SNED1 binds and transactivates insulin-like growth factor-binding protein-3 and other insulin responsive genes downstream of the phosphatidylinositol 3'-kinase/protein kinase B (Akt) pathway. SNED1 is localized to the cytoplasm in α, β, and δ-cells of the islets of Langerhans. Expression of SNED1 is decreased in diabetes and insulin-deficiency, suggesting that it plays a role in the mediation of insulin action. There are four isoforms of SNED1 that are produced as a result of alternative splicing events. |
