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SMA CRISPR Plasmids and si/shRNA Gene Silencers

Santa Cruz Biotechnology, Inc. offers a broad range of gene silencers in the form of siRNAs, shRNA Plasmids and shRNA Lentiviral Particles as well as CRISPR/Cas9 Knockout and CRISPR Double Nickase plasmids. SMA gene silencers are available as SMA siRNA, SMA shRNA Plasmid, SMA shRNA Lentiviral Particles and SMA CRISPR/Cas9 Knockout plasmids. SMA CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems for gene activation are also available. Gene silencers and activators are useful for gene studies in combination with antibodies used for protein detection.

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PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
SMA5 (D-18)
sc-324317goat IgGC-terminal (h)WB, IF, ELISAhuman1
SMA5 (N-17)
sc-324316goat IgGN-terminal (h)WB, IF, ELISAhumanNEW

SMA siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
SMA5 siRNA (h)
sc-92040humanGene SilencingN/A
SMA5 shRNA Plasmid (h)
sc-92040-SHhumanGene SilencingPuromycin
SMA5 shRNA (h) Lentiviral Particles
sc-92040-VhumanGene SilencingPuromycin

SMA5 is a 140 amino acid protein that is encoded by a gene mapping to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.