SIRT Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of SIRT antibodies. Select SIRT antibodies from several monoclonal and/or polyclonal SIRT antibodies listed below. View detailed SIRT antibody specifications by linking to the specific product blocks. Select appropriate SIRT antibodies for your research by isotype, epitope, applications and species reactivity. SIRT gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available.

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See SIRT Inhibitors or SIRT Activators for functional analysis of cellular responses to SIRT.

Also see additional SIRT Antibodies including, SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7... See More

Sirtuins (SIRT1-7) are human homologs of the yeast Sir2 (silent information regulator-2) protein and are divided into four main classes: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. In S. cerevisiae, Sir2 deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA (ribosomal DNA) and silent mating-type loci. The human SIRT proteins are NAD-dependent deacetylases that act as intracellular regulators and are thought to have ribosyltransferase activity. SIRT7 (NAD-dependent deacetylase sirtuin-7), also known as SIR2L7, is a member of the class IV sirtuin family and is localized to the nucleolus. Expressed throughout the body, SIRT7 associates with rDNA genes where it interacts with histones and acts as a positive regulator of RNA polymerase I (Pol I). SIRT7 is a probable NAD-dependent deacetylase whose expression is upregulated in thyroid carcinoma cells. Overexpression of SIRT7 increases Pol I-mediated transcription, thereby speeding cell growth and contributing to the development of cancer. Two isoforms exist due to alternative splicing events.