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SGT1 AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of SGT1 antibodies. Select SGT1 antibodies from several monoclonal and/or polyclonal SGT1 antibodies listed below. View detailed SGT1 antibody specifications by linking to the specific product blocks. Select appropriate SGT1 antibodies for your research by isotype, epitope, applications and species reactivity. Introducing HOVERcruz™,a unique system for rapid identification of SGT1 Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
Plants have evolved intricate defence mechanisms to cope with the wide array of microbial pathogens they encounter. Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination. Mutations in SGT1b, one of two highly homologous Arabidopsis SGT1 genes, disable early plant defenses conferred by multiple R genes. Loss of SGT1b function in resistance is not compensated for by SGT1a. SGT1 is required for resistance responses mediated by nucleotide-binding site/ leucine-rich repeat (NBS-LRR) and other R proteins in which pathogen-derived elicitors are recognized either inside or outside the host plant cell. |
