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rotatin AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of rotatin antibodies. Select rotatin antibodies from several monoclonal and/or polyclonal rotatin antibodies listed below. View detailed rotatin antibody specifications by linking to the specific product blocks. Select appropriate rotatin antibodies for your research by isotype, epitope, applications and species reactivity. rotatin gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of rotatin Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
rotatin siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
The vertebrate body appears externally symmetric, yet the central nervous system and visceral organs are arranged asymmetrically. Recent research suggests that a novel 2,226 amino acid protein called rotatin, which is also known as RTTN, FLJ26356, DKFZp434G145 or FLJ39085, is involved in the early developmental genetic cascade governing left-right specification and axial rotation. Rotatin regulates expression of essential left-right specification genes including Nodal, Lefty and Pitx2 and likely plays a role in notochord development. Studies suggest that rotatin deficiency elicits a recessive lethal mutation called nt (no turning) which causes defects in left-right and axial patterning. Five rotatin isoforms are known to exist as a result of alternative splicing, and the gene encoding rotatin maps to human chromosome 18q22.2. |
