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RIP AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of RIP antibodies. Select RIP antibodies from several monoclonal and/or polyclonal RIP antibodies listed below. View detailed RIP antibody specifications by linking to the specific product blocks. Select appropriate RIP antibodies for your research by isotype, epitope, applications and species reactivity. RIP gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of RIP Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.See RIP Inhibitors for functional analysis of cellular responses to RIP. Also see additional RIP Antibodies including, RIP3, RIP4, RIP5, RIP140, RIPX
RIP siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved "death domain" and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-R1 interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-R1-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-R1 via their DDH regions. Overexpression of TRADD leads to NFκB activation and apoptosis in the absence of TNF. Overexpression of FADD causes apoptosis, which can be blocked by the cow pox protein CrmA, suggesting that FADD lies upstream of ICE and possibly other serine proteases. The receptor interacting protein, RIP, associates with FAS exclusively via its DDH and this association is abrogated in lpr mutants. Unlike TRADD and FADD, RIP contains a putative amino terminal kinase domain. Several RIP family members exist. |
