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RETSAT AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of gene silencers in the form of siRNAs, shRNA Plasmids and shRNA Lentiviral Particles. RETSAT gene silencers are available as RETSAT siRNA, RETSAT shRNA Plasmid and RETSAT shRNA Lentiviral Particles. Gene silencers are useful for gene studies in combination with antibodies used for protein detection. Introducing HOVERcruz™,a unique system for rapid identification of RETSAT Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
RETSAT (retinol saturase (all-trans-retinol 13,14-reductase)), also known as all-trans-13,14-dihydroretinol saturase, is a 610 amino acid peripheral membrane protein of the endoplasmic reticulum that belongs to the carotenoid/retinoid oxidoreductase family and CrtISO subfamily. RETSAT saturates 13-14 double bonds of all-trans-retinol to form all-trans-13,14-dihydroretinol, and is implicated in both adipogenesis and vitamin A metabolism. Existing as two alternatively spliced isoforms, RETSAT is directly regulated by PPARγ and is induced during apoptosis. Considered a potential target for therapeutic intervention in metabolic disease, RETSAT is encoded by a gene located on human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alström syndrome. |