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Pre-TCR alpha AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of Pre-TCR alpha antibodies. Select Pre-TCR alpha antibodies from several monoclonal and/or polyclonal Pre-TCR alpha antibodies listed below. View detailed Pre-TCR alpha antibody specifications by linking to the specific product blocks. Select appropriate Pre-TCR alpha antibodies for your research by isotype, epitope, applications and species reactivity. Pre-TCR alpha gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of Pre-TCR alpha Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
Pre-TCR alpha siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
Maturation of cytotoxic T lymphocytes is mediated in part by a structure on the T cell surface known as the T cell antigen receptor (TCR) complex. The pre-TCR complex consists of pre-TCR α, pre-TCR βand CD3, which together help coordinate early thymocyte development. Pre-TCR α chain is a type I transmembrane glycoprotein with an extracellular region similar to the constant domain of the immunoglobulin supergene family. Notch3 transgenic mice lacking pre-TCR α inhibits tumor development. In humans, acute lymphoblastic leukemias (ALL) in remission have lower transcript levels of Notch3, HES-1 and pre-TCR α transcripts a and b relative to proliferating ALLs. The human pre-TCR α gene is expressed in immature T cells and maps to chromosome 6p21.3. |
