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PLEKHA AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of PLEKHA antibodies. Select PLEKHA antibodies from several monoclonal and/or polyclonal PLEKHA antibodies listed below. View detailed PLEKHA antibody specifications by linking to the specific product blocks. Select appropriate PLEKHA antibodies for your research by isotype, epitope, applications and species reactivity. PLEKHA gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of PLEKHA Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.Also see additional PLEKHA Antibodies including, PLEKHA4, PLEKHA5, PLEKHA6, PLEKHA7, PLEKHA9
PLEKHA siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
PLEKHA4 (Pleckstrin homology domain-containing family A member 4) specifically binds to PtdIns3P (phosphatidylinositol-3-phosphate), a phospholipid that resides on early endosomes, but not to other phosphoinositides. Though detected at low levels in normal skeletal muscle, small intestine, liver, heart and kidney, PLEKHA4 is found to be highly expressed in melanoma. PLEKHA5 is highly expressed in kidney and heart tissue. Ubiquitously expressed, with highest expression in heart, kidney and brain, PLEKHA6 exhibits phosphoinositide-binding specificity and participates in lipid-binding activities. Although PLEKHA6 is not known to be involved in signaling related to EGF receptors, which are expressed by many tumors, it is differentially phosphorylated between EGF receptor mutant and WT cell lines. PLEKHA7 interacts with the adherens junction protein p120 in human colon carcinoma cells. PLEKHA7 also colocalizes with zona adherens proteins and is necessary for zonula adherens biogenesis and maintenance. |
