PLC Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of PLC antibodies. Select PLC antibodies from several monoclonal and/or polyclonal PLC antibodies listed below. View detailed PLC antibody specifications by linking to the specific product blocks. Select appropriate PLC antibodies for your research by isotype, epitope, applications and species reactivity. PLC gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available.

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See PLC Inhibitors, PLC Activators or PLC Substrates for functional analysis of cellular responses to PLC.

Also see additional PLC Antibodies including, PLC beta 1, PLC beta 2, PLC beta 3, PLC beta 4, PLC delta 1, PLC delta 3, PLC delta 4... See More, PLC epsilon, PLC epsilon 2, PLC eta 1, PLC eta 2, PLC gamma 1, PLC gamma 2, PLC zeta, PLC-L, PLC-XD1

Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1, PLC δ2 and PLCε. PLC γ1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes and fibroblasts of the interstitial tissue. Actin-regulatory protein Villin is tyrosine phosphorylated and associates with PLC γ1 in the brush border of intestinal epithelial cells. Villin regulates PLC γ1 activity by modifying its own ability to bind phosphatidylinositol 4,5-biphosphate. PLC γ1 binds Integrin α1/β1 and modulates Integrin α1/β-specific adhesion. PLC γ1 and Ca²⁺ play a direct role in VEGF-regulated endothelial growth, however this signaling pathway is not linked to FGF-mediated effects in primary endothelial cells. PLC γ1 is rapidly activated in response to growth factor stimulation and plays an important role in regulating cell proliferation and differentiation. It may also have a protective function during cellular response to oxidative stress.