- Research Products Primary Antibodies: Mammalian Phospho-Specific Antibodies Antibodies for IHC (Paraffin) Staining Flow Cytometry Veterinary Research Antibodies Primary Antibodies: Non-Mammalian siRNA and shRNA (plasmid and lentivirus) Products Protein A, G PLUS and L-Agarose Tissue Extracts and Cell Lysates Biologically Active and Purified Proteins Transfected Cell Lysates Secondary Antibodies, Control Antibodies and Normal Sera Specialty Reagents and Kits
- Chemicals
- Lab Supplies
- Animal Health
- What's New
- Information
- Support
Welcome to Santa Cruz Biotechnology!
 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
PBGS AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of PBGS antibodies. Select PBGS antibodies from several monoclonal and/or polyclonal PBGS antibodies listed below. View detailed PBGS antibody specifications by linking to the specific product blocks. Select appropriate PBGS antibodies for your research by isotype, epitope, applications and species reactivity. PBGS gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of PBGS Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
PBGS siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
PGBS (porphobilinogen synthase), an enzyme that belongs to the ALADH family, is composed of eight identical subunits and catalyzes the condensation of two molecules of δ-aminolevulinate to form porphobilinogen, a precursor of heme, cytochromes and other hemoproteins. It also catalyzes the second step in the porphyrin and heme biosynthetic pathway in which zinc is essential for enzymatic activity. PGBS is inhibited by lead. A defect in the gene encoding PGBS, ALAD, can cause increased sensitivity to lead poisoning and acute hepatic porphyria, a group of inherited disorders caused by partial enzyme defects in heme biosynthesis, which includes acute intermittent porphyria, variegate porphyria and hereditary coproporphyria. There are two common alleles of ALAD, ALAD*2 and ALAD*1. When exposed to environmental lead, individuals heterozygous or homozygous for ALAD*2 Asn 59 have significantly higher blood lead levels than do ALAD*1 Lys 59 homozygotes. |
