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Patched, Smo and Hhip AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of gene silencers in the form of siRNAs, shRNA Plasmids and shRNA Lentiviral Particles. Patched, Smo and Hhip gene silencers are available as Patched, Smo and Hhip siRNA, Patched, Smo and Hhip shRNA Plasmid and Patched, Smo and Hhip shRNA Lentiviral Particles. Gene silencers are useful for gene studies in combination with antibodies used for protein detection. Introducing HOVERcruz™,a unique system for rapid identification of Patched, Smo and Hhip Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
Patched, Smo and Hhip siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
Hedgehog (Hh) signaling proteins are critical for growth and tissue patterning during development. Patched (Ptc), a putative 12 transmembrane receptor, binds to Sonic hedgehog and is suspected to be a negative regulator of Hh signaling. A family member of patched, designated patched 2, has been found to be co-expressed with Sonic hedgehog. Smoothened (Smo), a seven transmembrane receptor, is complexed with patched in many tissues and is believed to be an essential component in the Hh signaling pathway. Hhip (hedgehog-interacting protein) is able to bind to and may be a transcriptional target of all Hh proteins. Binding of Hhip to Hh proteins attenuates Hedgehog signaling. |
