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PAPP AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of PAPP antibodies. Select PAPP antibodies from several monoclonal and/or polyclonal PAPP antibodies listed below. View detailed PAPP antibody specifications by linking to the specific product blocks. Select appropriate PAPP antibodies for your research by isotype, epitope, applications and species reactivity. PAPP gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of PAPP Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.Also see additional PAPP Antibodies including, PAPP-A, PAPP-A2
PAPP siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
Pregnancy-associated plasma protein-A (Pappalysin-1 or PAPP-A), also known as Insulin-like growth factor-dependent IGF-binding protein 4 (IGFBP4) protease, is a member of the peptidase M43B family of proteins. PAPP-A, a metalloproteinase, cleaves Insulin-like growth factor binding proteins IGFBP4 and IGFBP5, releasing bound IGF. PAPP-A is primarily expressed in septa and anchoring villi in placenta and is also expressed in pregnancy serum. Levels of PAPP-A increase throughout pregnancy. Lower levels of expression can be detected in kidney, prostate, breast, ovary and endometrial tissues. PAPP-A is a secreted protein that can form homodimers; in pregnancy serum PAPP-A may also form a heterotetramer with PRG-2. |
