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ORNT AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of ORNT antibodies. Select ORNT antibodies from several monoclonal and/or polyclonal ORNT antibodies listed below. View detailed ORNT antibody specifications by linking to the specific product blocks. Select appropriate ORNT antibodies for your research by isotype, epitope, applications and species reactivity. ORNT gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of ORNT Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.Also see additional ORNT Antibodies including, ORNT1, ORNT2
ORNT siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
ORNT1 (mitochondrial ornithine transporter 1), also known as solute carrier family 25 member 15, is a 301 amino acid protein that is localized to the mitochondrial inner membrane. ORNT1 functions to transport ornithine across the inner membrane from the cytoplasm to the mitochondrial matrix, which is an essential step in the urea cycle, the process of eliminating toxic ammonium ions from the breakdown of amino acids. While it is expressed at very low levels in all other tissues, ORNT1 is relatively highly expressed in pancreas and liver. ORNT2 is also known as SLC25A2 and, like ORNT1, is a 301 amino acid protein that plays an essential role in ornithine transport. Defects in the gene encoding ORNT1 are the cause of hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH syndrome), an autosomal recessive disorder characterized by cerebellar ataxia, mental retardation and disturbance in consciousness. These symptoms are a result of defective ornithine transport, which prevents ammonia from being converted to urea and excreted, therefore leading to the buildup of ammonia buildup within the body. |
