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ORC Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of ORC antibodies. Select ORC antibodies from several monoclonal and/or polyclonal ORC antibodies listed below. View detailed ORC antibody specifications by linking to the specific product blocks. Select appropriate ORC antibodies for your research by isotype, epitope, applications and species reactivity. ORC gene silencer products in siRNA, shRNA Plasmid, shRNA Lentiviral Particle and CRISPR/Cas9 Knockout Plasmid formats are also available.

Introducing HOVERcruz™,

a unique system for rapid identification of ORC Antibodies. Hover over product names in the table to see representative data for each product.

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Our live chat system is available to answer your product and ordering questions.

Also see additional ORC Antibodies including, ORC1, ORC2, ORC3, ORC4, ORC5, ORC6

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
ORC1 (7A7)sc-23887rat IgG1FL (h)WB, IPhuman5
ORC1 (7F6/1)sc-53390mouse IgG1FL (h)WB, IPhuman
ORC1 (F-10)sc-398734mouse IgG1782-861 (h)WB, IP, IF, ELISAhumanNEW
ORC1 (H-80)sc-28741rabbit IgGC-terminal (h)WB, IP, IF, ELISAm, r, h, c, b, p2
ORC1 (N-17)sc-13231goat IgGN-terminal (h)WB, IF, IHC(P), ELISAm, r, h, c, b, p2
ORC1 (R-15)sc-13232goat IgGinternal (h)WB, IF, ELISAm, r, h1
ORC1 (3C166)sc-71751mouse IgG1FL (h)WB, IPhuman
ORC1 (3H2792)sc-71752mouse IgG1FL (h)WB, IPhuman
ORC2 (3G6)sc-32734rat IgG2aFL (h)WB, IPhuman7
ORC2 (C-18)sc-13238goat IgGC-terminal (h)WB, IP, IF, ELISAm, r, h, e, c, b11
ORC2 (H-300)sc-28742rabbit IgGC-terminal (h)WB, IP, IF, ELISAm, r, h, e, c, b6
ORC3 (H-97)sc-98930rabbit IgG617-707 (h)WB, IP, IF, ELISAm, r, h, e, c, b1
ORC3 (C-12)sc-374231mouse IgG1617-707 (h)WB, IP, IF, ELISAhuman
ORC3 (1D6)sc-23888rat IgG2bFL (h)WB, IP, IF, IHC(P)human5
ORC3 (G-20)sc-30957goat IgGC-terminal (h)WB, IF, ELISAm, r, h, e, c, b
ORC3 (K-17)sc-21862goat IgGC-terminal (h)WB, IF, ELISAm, r, h, e, c, b2
ORC3 (T-13)sc-21863goat IgGC-terminal (h)WB, IF, ELISAm, r, h, e, c, b
ORC4 (17)sc-136331mouse IgG1N/AWB, IFm, r, h
ORC4 (H-2)sc-398455mouse IgG1332-347 (h)WB, IP, IF, ELISAm, r, h, e, c, b, pNEW
ORC4 (C-15)sc-19726goat IgGC-terminal (h)WB, IP, IF, ELISAm, r, h, c
ORC4 (D-8)sc-393985mouse IgM375-398 (h)WB, IP, IF, ELISAm, r, hNEW
ORC4 (L-15)sc-19725goat IgGinternal (h)WB, IP, IF, ELISAm, r, h, e, c, b, p, a1
ORC4 (H-300)sc-20634rabbit IgG137-436 (h)WB, IP, IF, IHC(P), ELISAm, r, h, e, c, b, p4
ORC5 (H-300)sc-20635rabbit IgG136-435 (h)WB, IP, IF, ELISAm, r, h, e, c, b, a3
ORC5 (T-15)sc-19728goat IgGC-terminal (h)WB, IF, ELISAm, r, h, e, c1
ORC6 (D-4)sc-390490mouse IgG1FL (h)WB, IP, IF, ELISAm, hNEW
ORC6 (3A4)sc-32735rat IgG2aFL (h)WB, IP, IF, IHC(P)m, h3
ORC6 (FL-252)sc-20636rabbit IgGFL (h)WB, IP, IF, ELISAm, r, h
ORC6 (N-17)sc-19730goat IgGN-terminal (h)WB, IF, ELISAm, r, h
ORC6 (V-15)sc-19731goat IgGinternal (h)WB, IF, ELISAm, r, h, e, b, p
ORC6 (2679C2b)sc-81646mouse IgG1C-terminal (h)WB, IPhuman

Non-Mammalian ORC Antibodies

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
Orc1 (yC-20)sc-6675goat IgGC-terminal (Sc)WB, ELISAS. cerevisiae
Orc1 (yN-19)sc-6674goat IgGN-terminal (Sc)WB, ELISAS. cerevisiae
ORC1 (TK 1/2)sc-53391mouse IgG2aFL (x)WB, IP, ELISAXenopus
Orc2 (yC-19)sc-6677goat IgGC-terminal (Sc)WB, IP, ELISAS. cerevisiae1
Orc2 (C-5)sc-398410mouse IgG2a611-622 (S)WB, IP, IF, ELISAyNEW
Orc2 (yN-19)sc-6676goat IgGN-terminal (Sc)WB, ELISAS. cerevisiae
Orc2 (y-130)sc-28554rabbit IgG491-620 (Sc)WB, IP, IF, ELISAS. cerevisiae
Orc2 (SB46)sc-56738mouse IgG1FL (Sc)WB, IP, ELISAS. cerevisiae

ORC CRISPR/Cas9 Knockout Plasmids include:

PRODUCT NAMECAT. #APPLICATIONSSPECIESCITATIONS
ORC2 CRISPR/Cas9 KO Plasmid (h)sc-402746gene knockouthumanNEW
ORC4 CRISPR/Cas9 KO Plasmid (h)sc-403634gene knockouthumanNEW
ORC3 CRISPR/Cas9 KO Plasmid (h)sc-405473gene knockouthumanNEW
ORC6 CRISPR/Cas9 KO Plasmid (h)sc-405854gene knockouthumanNEW
ORC5 CRISPR/Cas9 KO Plasmid (h)sc-409147gene knockouthumanNEW
ORC1 CRISPR/Cas9 KO Plasmid (h)sc-418358gene knockouthumanNEW

ORC siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

siRNAsshRNA PlasmidsshRNA Lentiviral ParticlesCITATIONSRANKING
ORC1 siRNA (h): sc-38151ORC1 shRNA Plasmid (h):
sc-38151-SH
ORC1 shRNA (h)
Lentiviral Particles: sc-38151-V
Not Yet Rated
ORC1 siRNA (m): sc-38152ORC1 shRNA Plasmid (m):
sc-38152-SH
ORC1 shRNA (m)
Lentiviral Particles: sc-38152-V
Not Yet Rated
ORC2 siRNA (h): sc-38153ORC2 shRNA Plasmid (h):
sc-38153-SH
ORC2 shRNA (h)
Lentiviral Particles: sc-38153-V
ORC2 siRNA (m): sc-38154ORC2 shRNA Plasmid (m):
sc-38154-SH
ORC2 shRNA (m)
Lentiviral Particles: sc-38154-V
ORC3 siRNA (h): sc-38155ORC3 shRNA Plasmid (h):
sc-38155-SH
ORC3 shRNA (h)
Lentiviral Particles: sc-38155-V
Not Yet Rated
ORC3 siRNA (m): sc-38156ORC3 shRNA Plasmid (m):
sc-38156-SH
ORC3 shRNA (m)
Lentiviral Particles: sc-38156-V
Not Yet Rated
ORC4 siRNA (h): sc-38157ORC4 shRNA Plasmid (h):
sc-38157-SH
ORC4 shRNA (h)
Lentiviral Particles: sc-38157-V
Not Yet Rated
ORC4 siRNA (m): sc-38158ORC4 shRNA Plasmid (m):
sc-38158-SH
ORC4 shRNA (m)
Lentiviral Particles: sc-38158-V
Not Yet Rated
ORC5 siRNA (h): sc-38159ORC5 shRNA Plasmid (h):
sc-38159-SH
ORC5 shRNA (h)
Lentiviral Particles: sc-38159-V
Not Yet Rated
ORC5 siRNA (m): sc-38160ORC5 shRNA Plasmid (m):
sc-38160-SH
ORC5 shRNA (m)
Lentiviral Particles: sc-38160-V
Not Yet Rated
ORC6 siRNA (h): sc-38161ORC6 shRNA Plasmid (h):
sc-38161-SH
ORC6 shRNA (h)
Lentiviral Particles: sc-38161-V
Not Yet Rated
ORC6 siRNA (m): sc-38162ORC6 shRNA Plasmid (m):
sc-38162-SH
ORC6 shRNA (m)
Lentiviral Particles: sc-38162-V
Not Yet Rated

The initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes, which trigger initiation. Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins. ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors. Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues, such as the testis. ORC1 and ORC2 are both expressed at equivalent concentrations throughout the cell cycle; however, only ORC2 remains stably bound to chromatin. ORC4 and ORC6 are also expressed constantly throughout the cell cycle. ORC2, ORC3, ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble. The formation of this core complex suggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells.