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NXNL CRISPR Plasmids and si/shRNA Gene Silencers

Santa Cruz Biotechnology, Inc. offers a broad range of gene silencers in the form of siRNAs, shRNA Plasmids and shRNA Lentiviral Particles as well as CRISPR/Cas9 Knockout and CRISPR Double Nickase plasmids. NXNL gene silencers are available as NXNL siRNA, NXNL shRNA Plasmid, NXNL shRNA Lentiviral Particles and NXNL CRISPR/Cas9 Knockout plasmids. NXNL CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems for gene activation are also available. Gene silencers and activators are useful for gene studies in combination with antibodies used for protein detection.

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PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
NXNL2 (C-17)
sc-248125goat IgGInternal (h)WB, IP, IF, ELISAm, r, hNEW
NXNL2 (P-15)
sc-248123goat IgGInternal (h)WB, IF, ELISAm, r, hNEW

NXNL CRISPR Knockout, HDR and Nickase Knockout Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
NXNL2 CRISPR/Cas9 KO Plasmid (h)
sc-408554humanGene KnockoutGFPNEW
NXNL2 HDR Plasmid (h)
sc-408554-HDRhumanHomology Directed RepairPuromycinNEW
NXNL2 Double Nickase Plasmid (h)
sc-408554-NIChumanGene KnockoutPuromycinNEW
NXNL2 Double Nickase Plasmid (h2)
sc-408554-NIC-2humanGene KnockoutPuromycinNEW
NXNL2 CRISPR/Cas9 KO Plasmid (m)
sc-429023mouseGene KnockoutGFPNEW
NXNL2 HDR Plasmid (m)
sc-429023-HDRmouseHomology Directed RepairPuromycinNEW
NXNL2 Double Nickase Plasmid (m)
sc-429023-NICmouseGene KnockoutPuromycinNEW
NXNL2 Double Nickase Plasmid (m2)
sc-429023-NIC-2mouseGene KnockoutPuromycinNEW

NXNL CRISPR Activation Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
NXNL2 CRISPR Activation Plasmid (h)
sc-408554-ACThumanGene ActivationZeo, Blast, HygroNEW
NXNL2 CRISPR Activation Plasmid (h2)
sc-408554-ACT-2humanGene ActivationZeo, Blast, HygroNEW
NXNL2 Lentiviral Activation Particles (h)
sc-408554-LAChumanGene ActivationZeo, Blast, HygroNEW
NXNL2 Lentiviral Activation Particles (h2)
sc-408554-LAC-2humanGene ActivationZeo, Blast, HygroNEW
NXNL2 CRISPR Activation Plasmid (m)
sc-429023-ACTmouseGene ActivationZeo, Blast, HygroNEW
NXNL2 CRISPR Activation Plasmid (m2)
sc-429023-ACT-2mouseGene ActivationZeo, Blast, HygroNEW
NXNL2 Lentiviral Activation Particles (m)
sc-429023-LACmouseGene ActivationZeo, Blast, HygroNEW
NXNL2 Lentiviral Activation Particles (m2)
sc-429023-LAC-2mouseGene ActivationZeo, Blast, HygroNEW

NXNL siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
NXNL2 siRNA (h)
sc-92526humanGene SilencingN/A
NXNL2 shRNA Plasmid (h)
sc-92526-SHhumanGene SilencingPuromycin
NXNL2 shRNA (h) Lentiviral Particles
sc-92526-VhumanGene SilencingPuromycin
NXNL2 siRNA (m)
sc-150133mouseGene SilencingN/A
NXNL2 shRNA Plasmid (m)
sc-150133-SHmouseGene SilencingPuromycin
NXNL2 shRNA (m) Lentiviral Particles
sc-150133-VmouseGene SilencingPuromycin

NXNL2 (Nucleoredoxin-like protein 2) is a 156 amino acid protein belonging to the Nucleoredoxin family. Other members of the Nucleoredoxin family include Nucleoredoxin (NXN) and NXNL1 (Nucleoredoxin-like protein 1). NXNL2 contains a conserved 139 amino acid thioredoxin (Trx) domain. Thioredoxin serves as a general protein disulphide oxidoreductase. NXNL1 and NXNL2 have been shown to encode rod-derived cone viability factors, RdCVF and RdCVF2, respectively. Expressed in selected regions of the brain as well as the eye, NXNL2 maps to human chromosome 9q22.1 and mouse chromosome 13 A5. Two isoforms exist as a result of alternative splicing events.